31191-44-3

Usage

Chemical Properties

Slightly yellow low melting solid

InChI:InChI=1/C10H12BrNO3/c11-6-1-2-7-15-10-5-3-4-9(8-10)12(13)14/h3-5,8H,1-2,6-7H2

Upstream product

• 110-52-1 1,4-dibromo-butane 
• 554-84-7 meta-nitrophenol 

Downstream Products

• 913611-97-9 Brexpiprazole 
• 1257802-66-6 C₁₈H₂₀N₂O₆ 
• 1254951-56-8 tert-butyl 4-(4-(3-nitrophenoxy)butyl)piperazine-1-carboxylate 
• 1195950-26-5 C₁₁H₁₆N₂O₃ 
• 858136-25-1 bis(2-chloroethyl)-[4-(3-nitrophenoxy)butyl]amine 
• 858136-18-2 2-{(2-hydroxyethyl)-[4-(3-nitrophenoxy)butyl]amino}ethanol 
• 31185-42-9 4-[4-(3-Nitro-phenoxy)-butoxy]-benzenesulfonyl fluoride 

Relevant academic research and scientific papers

Novel method for preparing new antipsychotic drug brexpiprazole

The invention discloses a new electrochemical preparation method of a new antipsychotic drug brexpiprazole. The preparation method specifically comprises the following steps of: preparing a key intermediate, namely -1-(benzo [b] thiophene-4-yl)-4-(4-(-3nitrophenoxy) butyl) piperazine, and carrying out electric reduction on the key intermediate to prepare 3-[4-[4-(benzo [b] thiophene-4-yl) piperazine-1y-l] butoxy] aniline; and carrying out acylation reaction with cinnamyl chloride and intramolecular Friedel-Crafts acylation reaction to prepare brexpiprazole.

Piprazole antipsychotic drug key intermediate and electroreduction method thereof

The invention discloses a benzo [b] thiophene-4-yl) piperazine derivative shown as a formula I or a salt thereof, an electroreduction method of the benzo [b] thiophene-4-yl) piperazine derivative andapplication of the benzo [b] thiophene-4-yl) piperazine

Piperazine substituted 1, 3 - di-substituted urea compound and piperazine substituted amide compounds and a method for its preparation and use

The present invention relates to a class of piperazine substituted 1,3-disubstitued urea compounds and piperazine substituted amide compounds, or pharmaceutically acceptable salts of the piperazine substituted 1,3-disubstitued urea compounds and the piper

Incorporation of piperazino functionality into 1,3-disubstituted urea as the tertiary pharmacophore affording potent inhibitors of soluble epoxide hydrolase with improved pharmacokinetic properties

The inhibition of the mammalian soluble epoxide hydrolase (sEH) is a promising new therapy in the treatment of hypertension, inflammation, and other disorders. However, the problems of limited water solubility, high melting point, and low metabolic stabil

Synthesis and insecticidal activity of novel carbamate derivatives as potential dual-binding site acetylcholinesterase inhibitors

In biological systems, bivalent ligands often possess increased functional affinity for their receptors compared with monovalent ligands. On the basis of the structure of acetylcholinesterase (AChE), a series of novel carbamate heterodimetic derivatives w

Discovery of highly potent novel antifungal azoles by structure-based rational design

On the basis of the active site of lanosterol 14α-demethylase from Candida albicans (CACYP51), a series of new azoles were designed and synthesized. All the new azoles show excellent in vitro activity against most of the tested pathogenic fungi, which represent a class of promising leads for the development of novel antifungal agents. The MIC80 value of compounds 8c, 8i and 8n against C. albicans is 0.001 μg/mL, indicating that these compounds are more potent than fluconazole, itraconazole and voriconazole. Flexible molecular docking was used to analyze the structure-activity relationships (SARs) of the compounds. The designed compounds interact with CACYP51 through hydrophobic, van der Waals and hydrogen-bonding interactions.

9-anilinoacridine alkylating agents

This invention relates to 9-anilinoacridine alkylating agents, their synthesis and their use in pharmaceutical compositions for treating diseases.

Potent antitumor 9-anilinoacridines bearing an alkylating N-mustard residue on the anilino ring: Synthesis and biological activity

A series of N-mustard derivatives of 9-anilinoacridine was synthesized for antitumor and structure-activity relationship studies. The alkylating N-mustard residue was linked to the C-3′ or C-4′ position of the anilino ring with an O-ethylene (O-C2/s

PHOTOINDUCED INTRAMOLECULAR SUBSTITUTION-III PHOTOCYCLIZATION OF ω-ANILINOALKYL m-NITROPHENYL ETHERS

Irradiation of 1-(m-nitrophenoxy)-ω-anilinoalkanes, m-O2NC6H4O(CH2)nNHPh (n = 2 and 3) and their 1-(2-methoxy-5-nitrophenoxy) analogs induced intramolecular cyclization in which a hydrogen or methoxyl