312268-91-0

Basic information

• Product Name: 1H-Pyrrole-3-carboxylicacid, 2,5-dimethyl-4-(4-nitrophenyl)-, methyl ester
• Synonyms: 1H-Pyrrole-3-carboxylicacid,2,5-dimethyl-4-(4-nitrophenyl)-,methylester(9CI)
• CAS NO: 312268-91-0
• Molecular Formula: C14H14 N2 O4
• Molecular Weight: 274.27
• Product Categories: HANTZSCH
• Mol File: 312268-91-0.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1H-Pyrrole-3-carboxylicacid, 2,5-dimethyl-4-(4-nitrophenyl)-, methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Pyrrole-3-carboxylicacid, 2,5-dimethyl-4-(4-nitrophenyl)-, methyl ester(312268-91-0)
• EPA Substance Registry System: 1H-Pyrrole-3-carboxylicacid, 2,5-dimethyl-4-(4-nitrophenyl)-, methyl ester(312268-91-0)

Safety Data

• Hazardous Substances Data: 312268-91-0(Hazardous Substances Data)

Upstream product

• 6159-25-7 1-<(4-nitro)-phenyl>-1,2-propandione 
• 6078-06-4 (R)-methyl 3-aminobutanoate hydrochloride 
• 6078-06-4 methyl 3-aminobutyrate 

Relevant articles and documents

Transaminase-Mediated Amine Borrowing via Shuttle Biocatalysis

Shuttle catalysis has emerged as a useful methodology for the reversible transfer of small functional groups, such as CO and HCN, and goes far beyond transfer hydrogenation chemistry. While a biocatalytic hydrogen-borrowing methodology is well established, the biocatalytic borrowing of alternative functional groups has not yet been realized. Herein, we present a new concept of amine borrowing via biocatalytic shuttle catalysis, which has no counterpart in chemo-shuttle catalysis and allows efficient intermolecular amine shuttling to generate reactive intermediates in situ. By coupling this dynamic exchange with an irreversible downstream step to displace the reaction equilibrium in the forward direction, high conversion to target products can be achieved. We showcase the potential of this amine-borrowing methodology using a biocatalytic equivalent of both the Knorr-pyrrole synthesis and Pictet-Spengler reaction.