312299-66-4

Upstream product

• 642-71-7 3,4,5-trimethoxyphenol 
• 98-59-9 p-toluenesulfonyl chloride 

Downstream Products

• 1019107-63-1 5-phenyl-2-(3,4,5-trimethoxyphenyl)oxazole 
• 1126639-50-6 4-n-butyl-5-(3,4,5-trimethoxyphenyl)-1-(3-methylphenyl)-1H-1,2,3-triazole 
• 6443-69-2 3,4,5-trimethoxytoluene 
• 1262526-08-8 6-(3,4,5-trimethylphenyl)pyridazine 1-oxide 
• 1262526-15-7 2-(3,4,5-trimethoxyphenyl)pyrazine 1-oxide 
• 1262526-16-8 2-(3,4,5-trimethoxyphenyl)quinoline 1-oxide 
• 1262526-19-1 2-(3,4,5-trimethoxyphenyl)quinoxaline 1-oxide 

Relevant academic research and scientific papers

Nickel-catalyzed methylation of aryl halides/tosylates with methyl tosylate

This work describes the cross-electrophile methylation of aryl bromides and aryl tosylates with methyl tosylate. The mild reaction conditions allow effective methylation of a wide set of heteroaryl electrophiles and dimethylation of dibromoarenes.

Cell proliferation inhibitors

Compounds having formula (I) inhibit cellular proliferation. Processes for the preparation of the compounds, pharmaceutical compositions containing the compounds, and methods of treatment using the compounds are disclosed.

Novel sulfonate analogues of combretastatin A-4: Potent antimitotic agents

Sulfonate analogues of combretastatin A-4 have been prepared. These compounds compete with colchicine and combretastatin A-4 for the colchicine binding site on tubulin and are potent inhibitors of tubulin polymerization and cell proliferation. Importantly, these compounds also inhibit the proliferation of P-glycoprotein positive (+) cancer cells, which are resistant to many other antitumor agents.