3123-89-5Relevant articles and documents
Synthesis, antiproliferative activity and molecular docking of Colchicine derivatives
Huczyński, Adam,Majcher, Urszula,Maj, Ewa,Wietrzyk, Joanna,Janczak, Jan,Moshari, Mahshad,Tuszynski, Jack A.,Bartl, Franz
, p. 103 - 112 (2016)
In order to create more potent anticancer agents, a series of five structurally different derivatives of Colchicine have been synthesised. These compounds were characterised spectroscopically and structurally and their antiproliferative activity against f
Colchicine derivatives with potent anticancer activity and reduced P-glycoprotein induction liability
Singh, Baljinder,Kumar, Ashok,Joshi, Prashant,Guru, Santosh K.,Kumar, Suresh,Wani, Zahoor A.,Mahajan, Girish,Hussain, Aashiq,Qazi, Asif Khurshid,Kumar, Ajay,Bharate, Sonali S.,Gupta, Bishan D.,Sharma, Parduman R.,Hamid, Abid,Saxena, Ajit K.,Mondhe, Dilip M.,Bhushan, Shashi,Bharate, Sandip B.,Vishwakarma, Ram A.
, p. 5674 - 5689 (2015/05/27)
Colchicine (1), a nature-derived microtubule polymerization inhibitor, develops multi-drug resistance in tumor cells due to its P-gp substrate and induction activity, which in turn leads to its rapid efflux from tumor cells. This auto-induction of the eff
Antitumor agents. Part 186: Synthesis and biological evaluation of demethylcolchiceinamide analogues as cytotoxic DNA topoisomerase II inhibitors
Guan, Jian,Zhu, Xiao-Kang,Tachibana, Yoko,Bastow, Kenneth F.,Brossi, Arnold,Hamel, Ernest,Lee, Kuo-Hsiung
, p. 2127 - 2131 (2007/10/03)
Demethylation of colchiceinamide (2) and its analogues (3-10) afforded a novel class of mammalian DNA topoisomerase II inhibitors (2a-10a) without displaying tubulin inhibitory activity. All target compounds inhibited the catalytic activity of topoisomera
