312306-08-4

Upstream product

• 60456-26-0 (R)-glycidyl butyrate 
• 312306-04-0 benzyl 6-{[(benzyloxy)carbonyl]amino}-2-methyl-3,4-dihydro-1(2H)-quinolinecarboxylate 
• 649569-61-9 2-methyl-1,2,3,4-tetrahydro-quinolin-6-ylamine 
• 613-30-9 2-methyl-6-nitroquinoline 
• 65079-19-8 2-methylquinolin-6-amine 

Downstream Products

• 312306-10-8 benzyl (2R)-6-{(5S)-5-[(ethanethioylamino)methyl]-2-oxo-1,3-oxazolidin-3-yl}-2-methyl-3,4-dihydro-1(2H)-quinolinecarboxylate 
• 312306-09-5 Benzyl (2R)-6-{(5S)-5-[(acetylamino)methyl]-2-oxo-1,3-oxazolidin-3-yl}-2-methyl-3,4-dihydro-1(2H)-quinolinecarboxylate 

Relevant academic research and scientific papers

The effect of remote chirality on the antibacterial activity of indolinyl, tetrahydroquinolyl and dihydrobenzoxazinyl oxazolidinones

The oxazolidinones are promising agents for the treatment of infections caused by gram-positive bacteria, including multidrug-resistant strains. In ongoing studies we have discovered that a strategically placed chiral center of appropriate absolute configuration improves the antibacterial activity of indolinyl oxazolidinone analogues (gram-positive MIC's0.5 μg/mL for the most potent congeners). The design, synthesis, antibacterial activity and pharmacokinetic profile of a selected series of α-methylated indoline derivatives and a related set of tetrahydroquinolyl and dihydrobenzoxazinyl analogues are discussed.

Bicyclic oxazolidinones as antibacterial agents

The present invention provides compounds of formula I useful as antimicrobial agents wherein W, X, Y, R1, R2 and n are as defined in thereof.