312317-33-2

Upstream product

• 583-75-5 4-Bromo-2-methylaniline 
• 407-25-0 trifluoroacetic anhydride 

Downstream Products

• 183173-44-6 N-[4-bromo-2-(bromomethyl)phenyl]-2,2,2-trifluoroacetamide 
• 837392-59-3 [[5-bromo-2-(trifluoroacetamido)phenyl]methyl]triphenylphosphanium bromide 
• 837392-60-6 5-bromo-2-(trifluoromethyl)-1H-indole 
• 959158-03-3 [2-methyl-4-(4,4,5,5-tetramethyl-[3.2.1]dioxaborolan-2-yl)-phenyl]-trifluoroacetamide 

Relevant academic research and scientific papers

PARASITICIDAL COMPOSITIONS COMPRISING INDOLE DERIVATIVES, METHODS AND USES THEREOF

The invention relates to oral, topical or injectable compositions for combating liver fluke parasites in mammals, comprising at least one indole derivative active agent. The invention also provides for an improved method for eradicating and controlling liver fluke parasite infections and infestations in a mammal comprising administering the compositions of the invention to the mammal in need thereof.

Substituted 5-benzyl-2,4-diaminopyrimidines

The invention relates to substituted 5-benzyl-2,4-diaminopyrimidines of general formula (A) wherein R1is C2-C3 alkyl an R2is heterocyclyl, phenyl or naphthyl, bonded by one of its C-atoms and R3is C2-C6 alkyl, alkenyl, cycloalkyl, cycloalkylalkyl, heterocyclylalkyl, alkylsulfonyl, cycloalkylsulfonyl, cycloalkylalkylsulfamoyl, heterocyclysylfonyl, heterocyclylalkylsulfonyl or dialkylsulfamoyl; wherein alkyl, cycloalkyl and alyenyl can carry up to 6 carbon atoms alone or in compositions and can carry up to 6 ring members heterocyclically, alone, or in compositions and the groups R2and R3can be substituted; and to acid addition salts of compounds. The invention also relates to a method for producing the above 5-benzyl-2,4-diaminopyrimidines, to the intermediate. products that are produced, to corresponding medicaments and to the use of 5-benzyl-2,4-diaminopyrimidines as medicinal preparations. The products have antibiotic properties and are useful for combating or preventing infectious diseases.