183173-44-6

Upstream product

• 183173-36-6 N-(4-bromo-2-hydroxymethylphenyl)-2,2,2-trifluoroacetamide 
• 583-75-5 4-Bromo-2-methylaniline 
• 312317-33-2 N-(4-bromo-2-methylphenyl)-2,2,2-trifluoroacetamide 
• 20712-12-3 (2-amino-5-bromophenyl)methanol 
• 5344-90-1 2-Aminobenzyl alcohol 

Downstream Products

• 837392-59-3 [[5-bromo-2-(trifluoroacetamido)phenyl]methyl]triphenylphosphanium bromide 
• 837392-60-6 5-bromo-2-(trifluoromethyl)-1H-indole 
• 183173-58-2 1-benzenesulfonyl-5-bromo-1,3-dihydroindole-2,2-dicarboxylic acid dimethyl ester 
• 183173-63-9 5-bromo-1-phenylacetyl-1,3-dihydroindole-2,2-dicarboxylic acid dimethyl ester 
• 183173-61-7 1-benzyl-5-bromo-1,3-dihydroindole-2,2-dicarboxylic acid dimethyl ester 

Relevant academic research and scientific papers

PARASITICIDAL COMPOSITIONS COMPRISING INDOLE DERIVATIVES, METHODS AND USES THEREOF

The invention relates to oral, topical or injectable compositions for combating liver fluke parasites in mammals, comprising at least one indole derivative active agent. The invention also provides for an improved method for eradicating and controlling liver fluke parasite infections and infestations in a mammal comprising administering the compositions of the invention to the mammal in need thereof.

Thienopyridine and furopyridine kinase inhibitors

Compounds having the formula are useful for inhibiting protein tyrosine kinases. The present invention also discloses methods of making the compounds, compositions containing the compounds, and methods of treatment using the compounds.

HETEROCYCLIC BETA-ADRENERGIC AGONISTS

The present invention relates to certain compounds of the formula (I) the racemic-enantiomeric mixtures and optical isomers of said compounds and the pharmaceutically acceptable salts or prodrugs thereof, depicted below, which are β-adrenergic receptor agonists and accordingly have utility as, inter alia, hypoglycemic and antiobesity agents. More specifically, the compounds of the instant invention are selective agonists of β 3-adrenergic receptor. The invention also relates to methods of use for the compounds and to pharmaceutical compositions containing them. The compounds of the present invention also possess utility for increasing lean meat deposition and/or improving the lean meat to fat ratio in animals, e.g., ungulate animals, companion animals and poultry. The compounds have the formula STR1 wherein R. sup.1, R. sup.2, R 3, R 4, R 5, Y and Z are as defined in the specification.

A synthesis of functionalized indoline 2,2-biscarboxylates

A synthetic approach to a structurally novel series of indoline 2,2-biscarboxylates is described that employs a tandem bis-alkylation strategy to cyclize the indoline heteroring from the bromide 7 and diethyl bromomalonate. The indolines thus prepared may be N-deprotected and further functionalized on the indoline nitrogen.