312321-71-4

Basic information

• Product Name: 2-CHLOROMETHYL-4-NITRO-PYRIDINE
• Synonyms: 2-CHLOROMETHYL-4-NITRO-PYRIDINE;CHEMPACIFIC 38140;Pyridine, 2-(chloroMethyl)-4-nitro-
• CAS NO: 312321-71-4
• Molecular Formula: C₆H₅ClN₂O₂
• Molecular Weight: 172.57
• Mol File: 312321-71-4.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 305.6°C at 760 mmHg
• Flash Point: 138.6°C
• Appearance: /
• Density: 1.412g/cm³
• Vapor Pressure: 0.00147mmHg at 25°C
• Refractive Index: 1.579
• Storage Temp.: 2-8°C
• PKA: -0.20±0.20(Predicted)
• CAS DataBase Reference: 2-CHLOROMETHYL-4-NITRO-PYRIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-CHLOROMETHYL-4-NITRO-PYRIDINE(312321-71-4)
• EPA Substance Registry System: 2-CHLOROMETHYL-4-NITRO-PYRIDINE(312321-71-4)

Safety Data

• Hazardous Substances Data: 312321-71-4(Hazardous Substances Data)

Usage

General Description

2-Chloromethyl-4-nitro-pyridine is a chemical compound with the molecular formula C6H5ClN2O2. It is a yellow crystalline solid that is primarily used in the pharmaceutical industry as an intermediate for the synthesis of various drugs. 2-CHLOROMETHYL-4-NITRO-PYRIDINE is also used in the production of agricultural chemicals and dyes. It is classified as a hazardous substance and can cause skin and eye irritation upon contact. Additionally, it is considered to be harmful if swallowed or inhaled. Proper safety precautions including protective clothing and equipment should be used when handling this chemical.

InChI:InChI=1/C6H5ClN2O2/c7-4-5-3-6(9(10)11)1-2-8-5/h1-3H,4H2

Upstream product

• 5470-66-6 2-methyl-4-nitropyridine N-oxide 

Relevant articles and documents

Superoxide dismutase activity of iron(II)TPEN complex and its derivatives

Superoxide is involved in the pathogenesis of various diseases, such as inflammation, ischemia-reperfusion injury and carcinogenesis. Superoxide dismutases (SODs) catalyze the disproportionation reaction of superoxide to produce oxygen and hydrogen peroxide, and can protect living cells against the toxicity of free radicals derived from oxygen. Thus, SODs and their functional mimics have potential value as pharmaceuticals. We have previously reported that Fe(II)tetrakis-N,N,N',N'-(2-pyridylmethyl)ethylenediamine (Fe(II)TPEN) has an excellent SOD activity (IC50=0.5 μM) among many iron complexes examined (J. Biol. Chem., 264, 9243-9249 (1989)). Fe(II)TPEN can act like native SOD in living cells, and protect Escherichia coli cells from free radical toxicity caused by paraquat. In order to develop more effective SOD functional mimics, we synthesized Fe(II)TPEN derivatives with electron-donating or electron-withdrawing groups at the 4-position of all pyridines of TPEN, and measured the SOD activities and the redox potentials of these complexes. Fe(II) tetrakis-N,N,N',N'-(4-methoxy-2-pyridylmethyl)ethylenediamine (Fe(II)(4MeO)4TPEN) had the highest SOD activity (IC50=0.1 μM) among these iron-based SOD mimics. In addition, a good correlation was found between the redox potential and the SOD activity of 15 Fe(II) complexes, including iron-based SOD mimics reported in the previous paper (J. Organometal. Chem., in press). Iron-based SOD mimics may be clinically applicable, because these complexes are generally tissue-permeable and show low toxicity. Therefore our findings should be significant for the development of clinically useful SOD mimics.