312326-47-9

Upstream product

• 5694-95-1 2-(2-(2-hydroxyethyl)-1,3-dioxolan-2-yl)ethanol 
• 100-39-0 benzyl bromide 
• 1830-54-2 3-oxopentanedioic acid dimethyl ester 
• 6506-31-6 dimethyl acetonedicarboxylate ethylene ketal 

Downstream Products

• 312326-48-0 [2-(2-benzyloxy-ethyl)-[1,3]dioxolan-2-yl]-acetaldehyde 
• 312326-53-7 (Diethoxy-phosphoryl)-acetic acid (R)-5-benzyloxy-1-[(R)-2-(tert-butyl-diphenyl-silanyloxy)-1-methyl-ethyl]-3-oxo-pentyl ester 
• 312326-52-6 (Diethoxy-phosphoryl)-acetic acid (1R,2R)-1-[2-(2-benzyloxy-ethyl)-[1,3]dioxolan-2-ylmethyl]-3-(tert-butyl-diphenyl-silanyloxy)-2-methyl-propyl ester 
• 1009296-85-8 2-(2-(benzyloxy)ethyl)-2-(2-(trityloxy)ethyl)-1,3-dioxolane 
• 312326-51-5 (2R,3R)-1-[2-(2-Benzyloxy-ethyl)-[1,3]dioxolan-2-yl]-4-(tert-butyl-diphenyl-silanyloxy)-3-methyl-butan-2-ol 
• 312326-54-8 (R)-4-(2-Benzyloxy-ethyl)-6-[(R)-2-(tert-butyl-diphenyl-silanyloxy)-1-methyl-ethyl]-5,6-dihydro-pyran-2-one 
• 312326-49-1 (S)-4-Benzyl-3-{(2S,3R)-4-[2-(2-benzyloxy-ethyl)-[1,3]dioxolan-2-yl]-3-hydroxy-2-methyl-butyryl}-oxazolidin-2-one 
• 312326-55-9 (4R,6R)-6-[(R)-2-(tert-Butyl-diphenyl-silanyloxy)-1-methyl-ethyl]-4-(2-hydroxy-ethyl)-tetrahydro-pyran-2-one 
• 143521-72-6 {(2R,4S)-2-[(R)-2-(tert-Butyl-diphenyl-silanyloxy)-1-methyl-ethyl]-6-oxo-tetrahydro-pyran-4-yl}-acetaldehyde 
• 312326-50-4 (2R,3R)-4-[2-(2-Benzyloxy-ethyl)-[1,3]dioxolan-2-yl]-2-methyl-butane-1,3-diol 
• 143521-59-9 (E)-4-{(2R,4R)-2-[(R)-2-(tert-Butyl-diphenyl-silanyloxy)-1-methyl-ethyl]-6-oxo-tetrahydro-pyran-4-yl}-but-2-enoic acid ethyl ester 
• 362624-14-4 (E)-2-[(4S,6R)-6-((S)-2,4-Bis-benzyloxy-butyl)-2,2-dimethyl-[1,3]dioxan-4-yl]-6-{2-[(R)-2-(tert-butyl-dimethyl-silanyloxy)-3-methoxymethoxy-propyl]-[1,3]dioxolan-2-yl}-2-methyl-hex-4-en-3-one 
• 362624-15-5 3-[(4S,6R)-6-((S)-2,4-Bis-benzyloxy-butyl)-2,2-dimethyl-[1,3]dioxan-4-yl]-1-((7R,9R)-9-methoxymethoxymethyl-1,4,8-trioxa-spiro[4.5]dec-7-yl)-3-methyl-butan-2-one 
• 362624-08-6 4-[2-(2-benzyloxy-ethyl)-[1,3]dioxolan-2-yl]-3-(tert-butyl-dimethyl-silanyloxy)-butane-1,2-diol 

Relevant academic research and scientific papers

An approach towards the C1-C16 fragment of antineoplastic macrolide bryostatins by kinetic resolution of a racemic terminal epoxide using Jacobsen's catalyst

A stereo- and enantioselective approach towards the C1-C16 fragment of bryostatins is reported using Jacobsen's catalyst for kinetic resolution of a terminal epoxide, a Horner-Wadsworth-Emmons coupling reaction and a 1,4-Michael type cyclization as key steps.

Synthesis of a C1-C9 fragment of rhizoxin

A C1-C9 fragment of the antitumour macrolide rhizoxin has been synthesised. An Evans' asymmetric aldol reaction was used to set up the first two chiral centres, and an α,β-unsaturated δ-lactone was then formed on the acyclic system by an intramolecular Wadsworth-Emmons reaction. Stereoselective hydrogenation was used to set up the cis relative stereochemistry in the saturated δ-lactone ring. (C) 2000 Published by Elsevier Science Ltd.