31246-63-6

Basic information

• Product Name: {Pt(2)(OH)2}
• CAS NO: 31246-63-6
• Molecular Weight: 334.062
• Mol File: 31246-63-6.mol
• Article Data: 67

Chemical Properties

• CAS DataBase Reference: {Pt(2)(OH)2}(CAS DataBase Reference)
• NIST Chemistry Reference: {Pt(2)(OH)2}(31246-63-6)
• EPA Substance Registry System: {Pt(2)(OH)2}(31246-63-6)

Safety Data

• Hazardous Substances Data: 31246-63-6(Hazardous Substances Data)

Upstream product

• 7722-64-7 potassium permanganate 
• 26035-31-4 transplatin 
• 7722-84-1 dihydrogen peroxide 
• 26035-31-4 cisplatine 
• 7732-18-5 water 
• 15663-27-1 cisplatin 

Downstream Products

• 1613703-75-5 C₃₈H₃₆Cl₄N₄O₈Pt 
• 15663-27-1 cisplatin 
• 16893-05-3 cis-diaammineplatinum(IV) tetrachloride 

Relevant articles and documents

Intratumoral Cancer Chemotherapy with a Carrier-Based Immunogenic Cell-Death Eliciting Platinum (IV) Agent

A carrier-based, immunogenic cell death (ICD)-eliciting platinum(IV) chemotherapeutic agent was synthesized via complexation between an axially derivatized Pt(IV)-tocopherol and hyaluronan (HA)-tocopherol nanocarrier. The resultant HA-Pt(IV) complex demonstrated antiproliferative activity and induced calreticulin translocation, an indicator of ICD, in murine and human head and neck cancer (HNC) cells. The intratumorally administered HA-Pt(IV) treatments were tolerable and efficacious in both immunocompetent and immunodeficient mice with HNC, partially because of the direct cytotoxicity. Superior efficacy and survival were observed in the immunocompetent group, suggesting a possible Pt(IV)-induced immunological response, which would only manifest in animals with an intact immune system. Subsequent imaging of tumor tissues demonstrated increased macrophage infiltration in the HA-Pt(IV)-treated tumors compared to the nontreated controls and the cisplatin-treated tumors, suggesting favorable inflammatory activation. RNA sequencing of HA-Pt(IV)-treated tumors indicated that carbohydrate and vitamin metabolisms were the most important Kyoto Encyclopedia of Genes and Genomes pathways, and molecular function, biological process, and cellular component were highly enriched gene ontology categories.

High-activity Pt complex as well as preparation method and application thereof

The invention discloses a high-activity Pt (IV) complex, and belongs to the technical field of anticancer chemical drugs. The complex is represented by the general formula (1) or the general formula (2). General formula (1) (2) The invention introduces 6 - chloro -3 - methylbenzofuran -2 - formic acid or 5 -chloro -3 - methylbenzofuran -2 - formic acid into the platinum (IV) complex to significantly enhance the cytotoxicity of the platinum (IV) complex to cancer cells.

Tetravalent platinum complex containing posaconazole Preparation method and application thereof

The invention provides a tetravalent platinum complex containing posaconazole, a preparation method and application thereof, and the structure is shown in the formula I. The tetravalent platinum complex has obvious proliferation inhibition effect on liver cancer HepG2, lung cancer A549, colon cancer HCT116, breast cancer MDA-MB - 231 and cis-platinum drug-resistant lung adenocarcinoma, and the antitumor activity of the partial compound is obviously better than that of cisplatin. In addition, the complex has a remarkable inhibitory activity on common pathogenic fungi, shows significant inhibitory activity on posaconazole drug-resistant candida albicans, and can be used as a new drug for anti-tumor and antifungal candidate drugs.