Welcome to LookChem.com Sign In|Join Free
  • or

15663-27-1

Post Buying Request

15663-27-1 Suppliers

Recommended suppliersmore

Product FOB Price Min.Order Supply Ability Supplier
CISPLATIN with best price top supplier
Cas No: 15663-27-1
No Data 10 Gram 200 Kilogram/Month Hubei Jusheng Technology Co., Ltd., Contact Supplier
Cisplatin 99% Manufactuered in China best quality
Cas No: 15663-27-1
No Data 100 Gram Metric Ton/Day Wuhan Zenuo Biological Medicine Technology Co Ltd Contact Supplier
Good Price Quality Cisplatin Powder API
Cas No: 15663-27-1
USD $ 5.0-10.0 / Gram 1 Gram 10 Kilogram/Month Beijing Yibai Biotechnology Co., Ltd Contact Supplier
Cisplatin Manufacturer/High quality/Best price/In stock
Cas No: 15663-27-1
USD $ 3.0-3.0 / Kilogram 1 Kilogram 1-100 Metric Ton/Month Hangzhou Dayangchem Co., Ltd. Contact Supplier
Cisplatin/Cisplatinum/Cis-diamminedichloroplatinum(II)
Cas No: 15663-27-1
USD $ 28.0-28.0 / Gram 1 Gram 100 Metric Ton/Month Yurui(Shanghai)Chemical Co.,Ltd Contact Supplier
High purity 15663-27-1 cis-Dichlorodiamineplatinum(II)
Cas No: 15663-27-1
USD $ 100.0-500.0 / Gram 1 Gram 99999 Gram/Year Hangzhou Dingyan Chem Co., Ltd Contact Supplier
High quality Cisplatin with favourable price bulk in supply.
Cas No: 15663-27-1
USD $ 450.0-500.0 / Kilogram 1 Kilogram 5000 Kilogram/Week Kono Chem Co.,Ltd Contact Supplier
CAS 15663-27-1 Oxaliplatin
Cas No: 15663-27-1
USD $ 10.0-10.0 / Gram 1 Gram 10 Kilogram/Day Wuhan Vanz Pharm Inc. Contact Supplier
Factory Supply Good quality Cisplatin 15663-27-1
Cas No: 15663-27-1
No Data 1 Gram 5000 Kilogram/Month Hangzhou JINLAN Pharm-Drugs Technology Co., Ltd Contact Supplier
Cisplatin
Cas No: 15663-27-1
No Data 1 Kilogram 20 Metric Ton/Month Henan Allgreen Chemical Co.,Ltd Contact Supplier

15663-27-1 Usage

Purification Methods

Recrystallise it from dimethylformamide and check the purity by IR and UV-VIS spectroscopy. [Raudaschl et al. Inorg Chim Acta 78 143 1983.] HIGHLY TOXIC, SUSPECTED CARCINOGEN.

Fire Hazard

Flash point data for Cisplatin are not available; however, Cisplatin is probably combustible.

Uses

antitumor agent

Adverse reactions and side effects

Upon being subject to one-time injection of cisplatin for 50mg/m2, 25% to 30% of patients can get azotemia. Upon a larger dose and continuous medication, it can have serious and long-lasting kidney toxicity, manifested as tubular swelling, degenerative disease, elevated level of serum urea nitrogen, decreased creatinine clearance, hematuria, proteinuria, and even uremia.
It may have mild to moderate bone marrow toxicity whose degree depends on the amount of cisplatin. Anemia is common and may be accompanied with hemolysis. The patients can get severe nausea and vomiting which often appears at the beginning of treatment within 1h, lasting 8~12 h. The patients can administrate dexamethasone, ondansetron and diazepam to reduce the reaction.
It can cause malignant renal toxicity and is prone to occur at patients free from hydration and patients of diuretic therapy.
Combination with renal toxic antibiotics may increase the risk of enhancing acute renal failure.
It can commonly cause high-frequency hearing loss, and occasionally significant hearing loss. Tinnitus can occur at rare cases.
There may be significant symptoms of hyponatremia, hypomagnesemia, hypocalcemia, and hypokalemia which may occur in a few days after treatment.
After several times of administration can cause allergic reaction which can occur within minutes after administration, being manifested as facial edema, wheezing, tachycardia, etc. The patients should be quickly subject to anti-allergy measures such as antihistamine and adrenocorticotropic hormone.
There may be peripheral nerve toxicity. Hyperuricemia occurs rarely. There are occasional symptoms of orthostatic hypotension.

Definition

ChEBI: A diamminedichloroplatinum compound in which the two ammine ligands and two chloro ligands are oriented in a cis planar configuration around the central platinum ion. An anticancer drug that interacts with, and forms cross-links between, D A and proteins, it is used as a neoplasm inhibitor to treat solid tumours, primarily of the testis and ovary.

General Description

An anticancer drug. Orange-yellow to deep yellow solid or powder.

Uses

Used as an antineoplastic

Reactivity Profile

Cisplatin is incompatible with oxidizing agents. Cisplatin is also incompatible with aluminum. Cisplatin may react with sodium bisulfite and other antioxidants.

Pharmacological effects

Cisplatin is the most commonly used metal platinum complexes with the platinum atoms containing in the molecule being important for its anti tumor effect. However, it is also effective in the form of cis while being invalid in the Trans form. It can be cross-linked to DNA strand, showing cytotoxicity. After its dissolution inside the human body, it doesn’t need carrier transport in the body while being able to penetrate through the charged cell membrane. Owing to the low intracellular chloride concentration (4mmol /L), chloride ions are replaced by the water with the charge being positive which has a similar effect as bifunctional group of alkylating agent. It can combine with the nuclear DNA bases, forming three forms of cross-linking, resulting in DNA damage, further destroying DNA replication and transcription with the capability of inhibiting the synthesis of RNA and proteins at high concentrations as well. Cisplatin is characterized by broad anti-cancer spectrum, being effective in treating hypoxic cells and strong action. It has been widely used in the treatment of testicular cancer, ovarian cancer, uterine cancer, bladder cancer, cervical cancer, prostate cancer and brain cancer with significant efficacy. However, cisplatin has certain toxicity when being used in the treatment of cancer and thus being able to cause side effects. Therefore, it is necessary to continuously identify analogues of cisplatin with less toxicity and clinical effect being similar as cisplatin. So far scientists from various countries have been synthesized and tested thousands of cisplatin-related metal complexes and have developed the second-generation anti-cancer platinum complexes with carboplatin being the representative. The third generation anticancer metal complexes have also been identified with titanocene dichloride as the representative. These compounds have nothing to do with cisplatin from the chemical perspective but they have relative good efficacy in treating some kinds of cancer which can be hardly treated by cisplatin without doing harm to the kidney function. Now people in this area are continuing extensive research with the efforts majorly lining in exploring the anticancer mechanism of metal complexes at the molecular level. China has already started producing the goods of cisplatin and has carried out research in this area.
Cisplatin belongs to non-specific cell cycle drugs with cytotoxicity. Since the proliferation and synthesis rate of cancer cells is more rapid than normal cells, the cancer cell is more sensitive than normal cell to the toxic effects of this product. It can inhibit the DNA replication of cancer cell, and destroy the structure of the cell membrane. It has a strong broad-spectrum anti-cancer effect. It can be used for the treatment of ovarian cancer, prostate cancer, testicular cancer and other genitourinary malignancies with an excellent efficacy. When being used in combination with vincristine, cyclophosphamide and 5-fluorouracil, it has an excellent efficacy in the treatment of malignant lymphoma, breast cancer, carcinoma of head and neck squamous cell, thyroid cancer, and osteosarcoma, etc. Cisplatin, in combination with radiotherapy, can be used in the treatment for patients with advanced non-small cell lung cancer; nasopharyngeal cancer and esophageal cancer with prominent effect. It also has certain efficacy in the treatment of liver cancer and soft tissue sarcoma. Cisplatin, as a strong accumulative drug, is easy to produce renal toxicity with the gastrointestinal reactions being relatively common with neutropenia occurring in some patients but can be restored after the withdrawal of drugs for 7 to 14 days.
In addition, the DNA damage effect of this product can also possibly change the antigenicity in the nucleus or the cell surface so that the original hidden surface antigen is exposed, stimulating the immune suppression of antibodies and exert their cytotoxic effects.
This information is edited by Xiongfeng Dai from Chemicalbook.

Uses

muscle relaxant (skeletal)

Chemical Properties

Crystalline

History of discovery

Cisplatin is currently one of the most commonly used drugs used in combination chemotherapy with its chemical full name being cis-dichlorodiamineplatinum. It belongs to inorganic metal complexes. After the dissociation of the chlorine atom, it can be cross-linked with the DNA of the cancer cell DNA, thereby destroying the DNA function. It can form intra-strand or inter-strand crosslink with the DNA and may also form a cross-link with DNA and protein, and can inhibit cell mitosis, belonging to cell cycle non-specific drugs. In addition to its anti-cancer effect, it is still capable of inhibiting lymphocyte transformation and having immunosuppression effect and thus can be used as the metal complex-class anti-cancer drugs.
In 1844, it had been first successfully developed by the French chemist Mario Rampini and has been ever called Rampini's salt. It appears as an orange crystal. It has a small solubility (being 0.252 g/ 100 g of water at 25 ℃) and can be produced through the reaction between tetrachloro platinum (II) solution of potassium and ammonia.
In 1891, the modern founder of coordination chemistry, Werner, starting from the study of this class of compounds, had successfully established a complex theory, and clarified the cis structure of the Rampini's salt.
It was not until 1965 that the anticancer activity of cisplatin was found by Rosenberg and his colleagues from University of Michigan USA. When studying the effect of the electric filed on the growth of E. coli, they found that when putting into the metallic platinum to the medium containing ammonium chloride and then sending through 2 ampere for two hours, the reproduction of E. coli was inhibited. Further studies had showed that this is the effect of the cisplatin which is the product produced through the chemical reaction between the ammonia chloride and the platinum ion produced by electrolytic oxidation in the electrode. Rosenberg thought that given that cisplatin can prevent cell division, it should also have anticancer activity. Through the anti-cancer test, it has been proven that there is a good anti-cancer effect of cisplatin, drawing broad interest in metal complexes pharmacology. People had organized international cooperation research on chemistry, biology and medical field, finally enabling the successful applications of cisplatin in the treatment of cancer.
In December 1978, the US Food and Drug Administration had approved cisplatin for clinical application and make it as a commodity to supply the market. It has properties such as broad anti-tumor spectrum and being effective in treating hypoxic cells. However, it has toxicity to the kidneys, nervous system and pancreas. Modern pharmacology has classified this product as antineoplastic agents.

Biological Activity

Potent anticancer agent that blocks DNA synthesis. Induces apoptosis via p53-dependent and -independent mechanisms. Inhibits X-linked inhibitor of apoptosis protein (XIAP) expression and activates caspase-3. In certain glioma cell lines, sensitizes cells to TNF- α -induced apoptosis.

Air & Water Reactions

Insoluble in water.

Chemical Properties

It appears as orange or yellow crystalline powder with the Mp being 268-272°C (decomposition). It is slightly soluble in water and easily soluble in dimethylformamide. In aqueous solution, it can be gradually transformed into trans-and hydrolysis.
InChI:InChI=1/2ClH.2H3N.Pt/h2*1H;2*1H3;/q;;;;+2/p-2

15663-27-1 Well-known Company Product Price

Brand (Code)Product description CAS number Packaging Price Detail
Sigma (P4394)  cis-Diammineplatinum(II)dichloride  crystalline 15663-27-1 P4394-1G 4,351.23CNY Detail
Sigma (P4394)  cis-Diammineplatinum(II)dichloride  crystalline 15663-27-1 P4394-250MG 1,432.08CNY Detail
Sigma (P4394)  cis-Diammineplatinum(II)dichloride  crystalline 15663-27-1 P4394-100MG 872.82CNY Detail
Sigma (P4394)  cis-Diammineplatinum(II)dichloride  crystalline 15663-27-1 P4394-25MG 307.71CNY Detail
USP (1134357)  Cisplatin  United States Pharmacopeia (USP) Reference Standard 15663-27-1 1134357-100MG 4,588.74CNY Detail
Sigma-Aldrich (C2210000)  Cisplatin  European Pharmacopoeia (EP) Reference Standard 15663-27-1 C2210000 1,880.19CNY Detail
Aldrich (479306)  cis-Diamineplatinum(II) dichloride  ≥99.9% trace metals basis 15663-27-1 479306-50G 53,281.80CNY Detail
Aldrich (479306)  cis-Diamineplatinum(II) dichloride  ≥99.9% trace metals basis 15663-27-1 479306-5G 7,938.45CNY Detail
Aldrich (479306)  cis-Diamineplatinum(II) dichloride  ≥99.9% trace metals basis 15663-27-1 479306-1G 2,545.92CNY Detail
Sigma-Aldrich (PHR1624)  Cisplatin  pharmaceutical secondary standard; traceable to USP, PhEur 15663-27-1 PHR1624-200MG 1,437.35CNY Detail
Alfa Aesar (10471)  cis-Diamminedichloroplatinum(II), Pt 64.5% min    15663-27-1 5g 9349.0CNY Detail
Alfa Aesar (10471)  cis-Diamminedichloroplatinum(II), Pt 64.5% min    15663-27-1 1g 2084.0CNY Detail

15663-27-1SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 10, 2017

Revision Date: Aug 10, 2017

1.Identification

1.1 GHS Product identifier

Product name cisplatin

1.2 Other means of identification

Product number -
Other names cis-Dichlorodiammine platinum(II)

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:15663-27-1 SDS

Please post your buying leads,so that our qualified suppliers will soon contact you!

*Required Fields