31246-66-9

Basic information

• Product Name: cis,cis,trans-Diamminedichlorodihydroxoplatinum
• Synonyms: Oxoplatinum; Platinum,diamminedichlorodihydroxy-, stereoisomer (8CI); Oxo-Pt; Oxoplatin
• CAS NO: 31246-66-9
• Molecular Formula: Cl₂H₈N₂O₂Pt
• Molecular Weight: 334.0657
• Mol File: 31246-66-9.mol
• Article Data: 67

Chemical Properties

• CAS DataBase Reference: cis,cis,trans-Diamminedichlorodihydroxoplatinum(CAS DataBase Reference)
• NIST Chemistry Reference: cis,cis,trans-Diamminedichlorodihydroxoplatinum(31246-66-9)
• EPA Substance Registry System: cis,cis,trans-Diamminedichlorodihydroxoplatinum(31246-66-9)

Safety Data

• Hazardous Substances Data: 31246-66-9(Hazardous Substances Data)

Upstream product

• 15663-27-1 cisplatin 
• 7732-18-5 water 
• 26035-31-4 cisplatine 
• 7722-84-1 dihydrogen peroxide 
• 26035-31-4 transplatin 
• 7722-64-7 potassium permanganate 

Downstream Products

• 16893-05-3 cis-diaammineplatinum(IV) tetrachloride 
• 15663-27-1 cisplatin 

Relevant articles and documents

Quadrivalent platinum prodrug bendazac platinum, preparation thereof, and preparation methods and applications of prodrug and preparation

The invention belongs to the technical field of medicines, and particularly relates to a tetravalent platinum prodrug bendazac platinum, a preparation thereof, and preparation methods and applications of the prodrug and the preparation. The structural formula of the prodrug is shown in the specification. The preparation method of the prodrug comprises the following steps: (1) synthesizing hydroxyl platinum; (2) synthesizing bendazac platinum; and (3) purifying the bendazac platinum. The preparation method of the nano preparation comprises the following steps: (1) preparing a bendazac platinum solution; and (2) preparing the nano preparation by taking bovine serum albumin as a carrier. The tetravalent platinum prodrug bendazac platinum and the nano preparation thereof provided by the invention are good in water solubility, small in toxic and side effects and high in anti-tumor efficacy, can be passively targeted to a tumor site, can increase the drug uptake ability of tumor cells, and show a good anti-tumor effect, and the inhibition rates of the tetravalent platinum prodrug bendazac platinum to various tumors can be higher than 90%.

Human serum albumin loaded tetravalent platinum nanoparticles and preparation method thereof

The invention relates to human serum albumin loaded tetravalent platinum nanoparticles and a preparation method thereof, the nanoparticles are formed by self-assembly of albumin and a tetravalent platinum drug modified with double aliphatic chains, the structural formula of the tetravalent platinum drug is as shown in formula I or formula II, and n and m are respectively and independently selected from integers of 1-15. The nanoparticles can respond to the environment in tumor cells to release platinum drugs, therefore effectively reduce the system toxicity, overcome the drug resistance of the tumor cells, and have the advantage of enhancing the killing effect on the tumor cells.

Tetravalent platinum complex containing artesunate as well as preparation method and application of tetravalent platinum complex

The invention discloses a tetravalent platinum complex containing artesunate. The structure of the tetravalent platinum complex is shown as a general formula I or II, wherein R is shown in the specification, and R1 is a branched chain or straight chain saturated C1-C20 alkyl group, or a branched chain or straight chain unsaturated C1-C20 alkyl group. The tetravalent platinum complex containing artesunate provided by the invention has an obvious proliferation inhibition effect on liver cancer HepG2, lung cancer A549, intestinal cancer HCT116, breast cancer MDA-MB-231 and cis-platinum drug-resistant lung cancer, the anti-tumor activity of part of compounds is obviously superior to that of cis-platinum, and the tetravalent platinum complex containing artesunate can be used as anti-tumor candidate drugs for deeper research.