31248-69-8Relevant academic research and scientific papers
Synthesis of 13-Aza-18-nor-7-methyl-17-oxo-6-oxa-estra-1,3,5(10),9(11)-tetraene 3-Methyl Ether and 13-Aza-18-nor-7-methyl-17-oxo-6-thia-estra-1,3,5(10),9(11)-tetraene 3-Methyl Ether
Trehan, I. R.,Farwaha, Rajeev,Sharma, R. K.,Kaul, R. L.
, p. 87 - 89 (2007/10/02)
Modified Wittig reaction of chromanone (Ia) and thiochromanone (Ib) with triethylphosphonoacetate provides the conjugated esters (IIa and IIb) which on LAH reduction furnish the allylic alcohols (IIIa) and (IIIb) respectively.Alkylation of succinimide with IIIa and IIIb in the presence of triphenylphosphine and diethyl azodicarboxylate gives the seco-steroids (IVa) and (IVb) respectively.Reduction of these secosteroids with sodium borohydride at pH 3 results in the generation of ethoxyamides (Va and Vb) which on subsequent cyclization in the presence of PTS yield the title compounds (VIa) and (VIb) respectively.
