312492-83-4

Upstream product

• 73407-96-2 (2E,4E)-2-methyl-5-phenyl-penta-2,4-dienal 
• 73408-03-4 (E)-(S)-2-Methyl-5-phenyl-pent-4-enoic acid 
• 141423-26-9 <<3-(2S)-(4S)>-3-(2-Methyl-1-oxo-5-phenyl-pent-4-ene-4-(phenylmethyl))>-2-oxazolidinone 
• 312492-70-9 (4R,5S)-4-methyl-3-[(S,E)-2-methyl-5-phenylpent-4-enoyl]-5-phenyloxazolidin-2-one 
• 77877-20-4 (4R,5S)-4-methyl-5-phenyl-3-propionyloxazolidin-2-one 
• 4392-24-9 Cinnamyl bromide 

Downstream Products

• 312492-71-0 (S,E)-(tert-butyl)-dimethyl-(2-methyl-5-phenylpent-4-enyloxy)silane 
• 73407-98-4 ((R)-4,8-dimethyl-non-1-en-t-yl)-benzene 
• 73408-00-1 ((4R,8R)-4,8,12-trimethyl-tridec-1-en-t-yl)-benzene 
• 141423-25-8 <<3-(2R,4S,5S,6R,8E),4R>-3-(5-Hydroxy-2,4,6-trimethyl-1,3-dioxo-9-phenyl-8-nonenyl)-4-(phenylmethyl)>-2-oxazolidinone 
• 141423-25-8 <<3-(2R,4R,5R,6R,8E),4R>-3-(5-Hydroxy-2,4,6-trimethyl-1,3-dioxo-9-phenyl-8-nonenyl)-4-(phenylmethyl)>-2-oxazolidinone 
• 312492-77-6 (4S,5R)-3-[(S)-3-{(4R,5R)-5-[(S)-5-(tert-butyldimethylsilyloxy)-4-methylpentyl]-2,2,5-trimethyl-1,3-dioxolan-4-yl}-2-hydroxypropanoyl]-4-methyl-5-phenyloxazolidin-2-one 
• 312492-76-5 (4S,5R)-3-(3-{(4R,5R)-5-[(S)-5-(tert-butyldimethylsilyloxy)-4-methylpentyl]-2,2,5-trimethyl-1,3-dioxolan-4-yl}propanoyl)-4-methyl-5-phenyloxazolidin-2-one 
• 312492-75-4 ((S)-5-{(4R,5R)-5-[3-(benzyloxy)propyl]-2,2,4-trimethyl-1,3-dioxolan-4-yl}-2-methylpent-4-enyloxy)(tert-butyl)dimethylsilane 

Relevant academic research and scientific papers

New solutions to the C-12,13 stereoproblem of epothilones B and D; synthesis of a 12,13-diol-acetonide epothilone B analog

New approaches are described to the synthesis of epothilone B and a 12,13-diol-acetonide derivative. Specifically the (12Z) double bond is formed quantitatively by a silicon-tethered ring-closing metathesis (RCM) reaction with 85 % selectivity. Alternatively, a direct route to the 12,13-epoxide by cyclization of a 12,13-diol has been developed. Wiley-VCH Verlag GmbH & Co. KGaA, 2006.

A novel highly stereoselective total synthesis of epothilone B and of its (12R, 13R) acetonide

Stereoselective syntheses of epothilone B (1) and its novel derivative 2 are described. Key steps are the formation of intermediate 3 via Sharpless AD-reaction and Davis-Evans-hydroxylation. (C) 2000 Elsevier Science Ltd.

Diastereoselective anti aldol reactions of chiral ethyl ketones. Enantioselective processes for the synthesis of polypropionate natural products

The diastereoselective anti aldol reactions of the β-keto imide 3a, the related ethyl ketone 20b, and its diastereomer 22b have been studied. In these aldol reactions, the chiral ethyl ketones 3a and 20b were found to exhibit the opposite sense of asymmet