73408-03-4

Upstream product

• 103-26-4 methyl cinnamate 
• 20414-94-2 (2E,4E)-2-methyl-5-phenyl-2,4-pentadienoic acid 
• 20414-93-1 E-methyl-2-phenyl-5-pentadien-2,4-oate de methyle 
• 104-55-2 3-phenyl-propenal 
• 100-52-7 benzaldehyde 
• 104-54-1 3-Phenylpropenol 

Downstream Products

• 312492-83-4 (2S,4E)-2-methyl-5-phenyl-4-penten-1-ol 
• 73407-98-4 ((R)-4,8-dimethyl-non-1-en-t-yl)-benzene 
• 73408-00-1 ((4R,8R)-4,8,12-trimethyl-tridec-1-en-t-yl)-benzene 
• 73407-99-5 Toluene-4-sulfonic acid (E)-(S)-2-methyl-5-phenyl-pent-4-enyl ester 

Relevant academic research and scientific papers

Highly Regio- A nd Enantioselective Hydrogenation of Conjugated α-Substituted Dienoic Acids

Highly regio- A nd enantioselective hydrogenation of conjugated α-substituted dienoic acids was realized for the first time using Trifer-Rh complex, providing a straightforward method for the synthesis of chiral α-substituted ?,?′-unsaturated acids. DFT calculations revealed N+H-O hydrogen bonding interaction is formed to stabilize the transition state and the coordination of 4,5-double bond to Rh(III) center would facilitate the reductive elimination process. This hydrogenation provided a gram-scale synthesis of the precursor of sacubitril.