31253-16-4

Upstream product

• 79-24-3 Nitroethane 
• 99-61-6 3-nitro-benzaldehyde 

Downstream Products

• 115170-83-7 1-(1-Methoxy-2-nitro-propyl)-3-nitro-benzene 
• 29865-59-6 1-(m-Nitro-phenyl)-2-nitro-propane 
• 1451-81-6 1-m-Nitrophenyl-1-methoxy-aceton 
• 142528-64-1 2-methyl-2-nitro-3-(3-nitrophenyl)oxirane 
• 5881-71-0 Methyl<2,5-dimethyl-4-(3-nitrophenyl)-3-pyrrolyl>keton 
• 921-11-9 2,3,4-pentanetrione 
• 91473-87-9 5-<(Acetyl)(methoxycarbonyl)methylenamino>-4,5-dihydro-2,5-dimethyl-4-(3-nitrophenyl)-3-furancarbonsaeure-methylester 
• 1723-25-7 ethyl 2,3-dioxobutyrate 
• 5881-62-9 2,5-Dimethyl-4-(3-nitrophenyl)-3-pyrrolcarbonsaeure-ethylester 

Relevant academic research and scientific papers

Phenylpyrrolic compounds used as drugs, their preparation and application

The present invention relates to phenylpyrrole compounds, pharmaceutical compositions, preparation and to their application as an active principle, especially as a drug having antimitotic activity.

Compounds interacting with tubulin: Part I: Synthesis of ortho-ortho' substituted phenylpyrroles with free or restricted rotation.

The synthesis of ortho-ortho' substituted phenylpyrroles that are susceptible to isomerization of the biaryl type (atropisomerism) was performed using a Michael addition of isocyanoacetates with nitrostyrenes.Atropisomerism in phenylpyrroles 14 and 15 was studied by means of 1H NMR spectroscopy using chiral lanthanide shift reagents (LSR*).In the case of chiral phenylpyrrole 21, an evaluation of the interconversion parameters between diastereomers (k, ΔGT*) was attempted. - - - tubulin / phenylpyrrole / atropisomers / chiral shift reagents

HENRY CONDENSATION UNDER HIGH PRESSURE. 2. EFFECT OF AROMATIC ALDEHYDE TYPE AND PRESSURE ON THE YIELD OF ω-NITROSTYRENES AND SECONDARY PROCESSES

Condensation of aromatic aldehydes (I)-(XX) with EtNO2 and n-PrNO2 in AcOH in the presence of AcONH4 or i-BuNH2 gives primarily ω-nitrostyrenes (Ia, b) - (XXa, b) and small quantities of nitriles (Ic) - (XXc), oximes (Id) - (XXd), and ketones (Ie, f) - (XXe, f).The yields of (Ia, b) - (XXa, b) at P = 1 atm are higher for acceptor substitutents on the aromatic ring whereas at P = 10 kbar, they are higher for donor substituents.High pressures suppress the formation of (Ic-f) - (XXc-f) and the Z-isomers of (Ia, b) - (XXa, b).The high pressure technique is especially useful in the preparation of donor-substituted (Ia, b) - (XXa, b) which are intermediates in the synthesis of the psychotropic β-phenylethylamines.