1723-25-7Relevant articles and documents
Simple synthesis process of ethyl 5-methyl-1H-pyrazole-3-formate
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Paragraph 0015-0017, (2021/02/24)
The invention discloses a simple synthesis process of ethyl 5-methyl-1H-pyrazole-3-formate, which comprises the following steps: by using diethyl oxalate and acetone as main raw materials, ethanol asa solvent and sodium ethoxide as alkali, carrying out condensation reaction to prepare an intermediate, and carrying out cyclization on the intermediate and hydrazine hydrate under an acidic conditionto synthesize ethyl 5-methyl-1H-pyrazole-3-formate. The whole process has the advantages of simple and accessible raw materials, simple and feasible operation and favorable economic benefit.
Synthesis method of 1, 3-dimethyl-1H-pyrazole-5-ethyl formate
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Paragraph 0009-0010, (2021/01/30)
The invention relates to a synthesis method of 1, 3-dimethyl-1H-pyrazole-5-ethyl formate. The synthesis method comprises the following steps: 1. mixing ethanol, sodium ethoxide and diethyl oxalate, dropwisely adding acetone into the reaction solution reversely and slowly, keeping the internal temperature at 15 DEG C or below, and carrying out heat-preservation reaction for 24 hours to obtain an intermediate; 2, mixing DMF and the intermediate obtained in the step 1, cooling the reaction solution to 5-15 DEG C, slowly dropwise adding methylhydrazine into the reaction solution, and maintaining the internal temperature to be below 15 DEG C; after dropping, heating to 40-50 DEG C, and keeping the temperature to react for 6 hours; adding a reaction solution; concentrating under reduced pressureto obtain a crude product; and further carrying out reduced pressure distillation on the crude product to prepare the 1, 3-dimethyl-1H-pyrazole-5-ethyl formate. The method is simple and easy to obtain, reaction is easy to control, and aftertreatment is simple. By controlling the temperature and the feeding sequence, the conversion rate of the product is effectively increased, the content of impurities is inhibited, and the purity and the yield of the product are improved.
Facile synthesis of 1,2,3-tricarbonyls from 1,3-dicarbonyls mediated by cerium(IV) ammonium nitrate
Sivan, Akhil,Deepthi, Ani
supporting information, p. 1890 - 1893 (2014/03/21)
A mild and efficient protocol for the synthesis of vicinal tricarbonyl compounds from β-dicarbonyls in a single step using cerium(IV) ammonium nitrate as a catalytic oxidant is described. Ease of execution, wide substrate scope and the suitability for the synthesis of commercially important compounds like ninhydrin, alloxan and oxoline make this reaction particularly noteworthy.
