31255-13-7

Basic information

• Product Name: 7,16-dimethyl-7,16-diaza-1,4,10,13-tetraoxacyclooctadecane
• Synonyms: 7,16-dimethyl-7,16-diaza-1,4,10,13-tetraoxacyclooctadecane
• CAS NO: 31255-13-7
• Molecular Weight: 290.403
• Mol File: 31255-13-7.mol

Chemical Properties

• CAS DataBase Reference: 7,16-dimethyl-7,16-diaza-1,4,10,13-tetraoxacyclooctadecane(CAS DataBase Reference)
• NIST Chemistry Reference: 7,16-dimethyl-7,16-diaza-1,4,10,13-tetraoxacyclooctadecane(31255-13-7)
• EPA Substance Registry System: 7,16-dimethyl-7,16-diaza-1,4,10,13-tetraoxacyclooctadecane(31255-13-7)

Safety Data

• Hazardous Substances Data: 31255-13-7(Hazardous Substances Data)

Upstream product

• 19249-03-7 triethylene glycol di-(p-toluenesulfonate) 
• 3065-46-1 1,2-bis-(2-dimethylamino-ethoxy)-ethane 

Downstream Products

• 31364-42-8 kryptofix 221 
• 23978-09-8 [2.2.2]cryptande 

Relevant articles and documents

Synthesis of N,N'-dimethyl diazacoronands via double-quaternization reaction

α,ω-Tertiary diamines react under high pressure with α,ω-di-lodo compounds to give the cyclic bis-quaternary salts in almost quantitative yields. It is also shown that the same reaction can be carried out under atmospheric-pressure conditions with slightly lower yields. Subsequent demethylation of the bis-quaternary salts with triphenylphosphine affords N,N'-dimethyl diazcoronands in high yield.

High-pressure Approach to the Synthesis of N,N'-Dimethyl Diazacoronands

α,ω-Tertiary diamines react under high pressure with α,ω-di-iodo compounds to give the cyclic bis-quaternary salts in almost quantitative yields and their subsequent demethylation with triphenylphosphine affords N,N'-dimethyl diazacoronands in high yield.

Efficient Synthesis of N,N'-Dimethyl Diazacoronands

Modification of the Richman and Atkins method for preparation of symmetric and nonsymmetric bis-(p-toluenesulphonyl) diazacoronands is reported.The one-pot transformation of these compounds into N,N'-dimethyl diazacoronands is also described.