31255-13-7

Upstream product

• 3065-46-1 1,2-bis-(2-dimethylamino-ethoxy)-ethane 
• 19249-03-7 triethylene glycol di-(p-toluenesulfonate) 

Downstream Products

• 31364-42-8 kryptofix 221 
• 23978-09-8 [2.2.2]cryptande 

Relevant academic research and scientific papers

Synthesis of N,N'-dimethyl diazacoronands via double-quaternization reaction

α,ω-Tertiary diamines react under high pressure with α,ω-di-lodo compounds to give the cyclic bis-quaternary salts in almost quantitative yields. It is also shown that the same reaction can be carried out under atmospheric-pressure conditions with slightly lower yields. Subsequent demethylation of the bis-quaternary salts with triphenylphosphine affords N,N'-dimethyl diazcoronands in high yield.

High-pressure Approach to the Synthesis of N,N'-Dimethyl Diazacoronands

α,ω-Tertiary diamines react under high pressure with α,ω-di-iodo compounds to give the cyclic bis-quaternary salts in almost quantitative yields and their subsequent demethylation with triphenylphosphine affords N,N'-dimethyl diazacoronands in high yield.

Efficient Synthesis of N,N'-Dimethyl Diazacoronands

Modification of the Richman and Atkins method for preparation of symmetric and nonsymmetric bis-(p-toluenesulphonyl) diazacoronands is reported.The one-pot transformation of these compounds into N,N'-dimethyl diazacoronands is also described.