31255-57-9

Basic information

• Product Name: 3-[2-(3-Chlorophenyl)ethyl]-2-pyridinecarbonitrile
• Synonyms: 3-[2-(3-CHLOROPHENYL)-ETHYL]-PYRIDINE-2-CARBONITRILE;3-[2-(3-CHLOROPHENYL)-ETHYL]-PYRIDINE CARBONITRILE;3-[2-(3-CHLOROPHENYL)ETHYL]-2-CYANOPYRIDINE;3-(2-(3-CHLORO PHENYL)ETHYL)-2-PYRIDINE CARBONITRILE;3-[2-(3-CHLOROBENZENE)ETHYL]-PYRIDINITRILE;3-K2-(3-CHLOROPHENYLJETHYLL-PYRIDINE CARBONITRILE;3-(M-Chlorophenethyl)picolinonitrile;Loratadine Cyano IMpurity
• CAS NO: 31255-57-9
• Molecular Formula: C₁₄H₁₁ClN₂
• Molecular Weight: 242.7
• EINECS: 145-896-5
• Product Categories: Pyridine;Aromatics;Bases & Related Reagents;Nucleotides
• Mol File: 31255-57-9.mol
• Article Data: 21

Chemical Properties

• Melting Point: 71-72°C
• Boiling Point: 375.7 °C at 760 mmHg
• Flash Point: 181 °C
• Appearance: Light brown solid
• Density: 1.23 g/cm³
• Vapor Pressure: 7.65E-06mmHg at 25°C
• Refractive Index: 1.605
• Storage Temp.: Refrigerator
• PKA: -0.15±0.10(Predicted)
• CAS DataBase Reference: 3-[2-(3-Chlorophenyl)ethyl]-2-pyridinecarbonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 3-[2-(3-Chlorophenyl)ethyl]-2-pyridinecarbonitrile(31255-57-9)
• EPA Substance Registry System: 3-[2-(3-Chlorophenyl)ethyl]-2-pyridinecarbonitrile(31255-57-9)

Safety Data

• Hazardous Substances Data: 31255-57-9(Hazardous Substances Data)

Usage

Chemical Properties

Light Brown Solid

Uses

2-Cyano-3-(3-chlorophenylethyl)pyridine (cas# 31255-57-9) is a compound useful in organic synthesis.

InChI:InChI=1/C14H11ClN2/c15-13-5-1-3-11(9-13)6-7-12-4-2-8-17-14(12)10-16/h1-5,8-9H,6-7H2

Synthetic route

3-[2-(3-chlorophenyl)vinyl]-2-pyridinecarbonitrile → 3-[2-(3-chlorophenyl)ethyl]-2-pyridine-carbonitrile (31255-57-9)

Conditions	Yield
With palladium 10% on activated carbon; hydrogen In tetrahydrofuran; methanol at 20℃; under 760.051 Torr; for 24h; Reagent/catalyst; Solvent;	96%

3-<2-(3-chlorophenyl)ethyl>-N-(1,1-dimethylethyl)-2-pyridinecarboxamide (107285-30-3) → 3-[2-(3-chlorophenyl)ethyl]-2-pyridine-carbonitrile (31255-57-9)

Conditions	Yield
With trichlorophosphate In toluene for 4h; Reflux;	74%
With trichlorophosphate at 80℃; for 2.5h;	68.1%
With trichlorophosphate for 5h; Heating / reflux;	63%

3-(3-chlorophenethyl)-pyridine N-oxide (31255-47-7) + sodium cyanide (143-33-9) → 3-[2-(3-chlorophenyl)ethyl]-2-pyridine-carbonitrile (31255-57-9)

Conditions	Yield
Stage #1: 3-(3-chlorophenethyl)-pyridine N-oxide With N,N-Dimethylcarbamoyl chloride In acetonitrile at 35 - 40℃; for 1 - 3h; Stage #2: sodium cyanide In water; acetonitrile at -5 - 0℃; for 3 - 4h; Stage #3: With sodium hydroxide In water; acetonitrile for 2 - 3h;	73.5%

2-cyano-3-methylpyridine (20970-75-6) → 3-[2-(3-chlorophenyl)ethyl]-2-pyridine-carbonitrile (31255-57-9)

Conditions	Yield
Multi-step reaction with 3 steps 1: 97 percent / conc. H2SO4 / 0.5 h / 75 °C 2: 1.) n-BuLi, NaBr / 1.) THF, hexane, -40 deg C, 10 min, 2.) THF, hexane, -40 deg C, 30 min 3: 1.) POCl3, 2.) 50percent aq. NaOH / 1.) reflux, 3 h, 2.) 30 deg C, 2 h, pH 8 View Scheme
Multi-step reaction with 3 steps 1: N-chloro-succinimide; dibenzoyl peroxide / tetrachloromethane / 48 h / Reflux 2: magnesium; iodine / tetrahydrofuran / 1 h / 35 - 40 °C / Inert atmosphere 3: palladium 10% on activated carbon / tetrahydrofuran / 12 h / 25 - 35 °C View Scheme
Multi-step reaction with 3 steps 1.1: sulfuric acid / 0.5 h / 70 - 75 °C 2.1: n-butyllithium / tetrahydrofuran / 0.33 h / -30 - -10 °C / Inert atmosphere 2.2: 1 h / -10 °C / Inert atmosphere 3.1: trichlorophosphate / 4 h / 110 °C View Scheme
Multi-step reaction with 3 steps 1.1: sulfuric acid; water; acetic acid / 60 °C 1.2: 2.5 h / 70 - 80 °C 2.1: n-butyllithium; sodium bromide / tetrahydrofuran / 0.5 h / 0 °C / Inert atmosphere 2.2: 2 h / Inert atmosphere 3.1: trichlorophosphate / 2.5 h / 80 °C View Scheme

N-tert-butyl-3-methylpyridine-2-carboxamide (32998-95-1) → 3-[2-(3-chlorophenyl)ethyl]-2-pyridine-carbonitrile (31255-57-9)

Conditions	Yield
Multi-step reaction with 2 steps 1: 1.) n-BuLi, NaBr / 1.) THF, hexane, -40 deg C, 10 min, 2.) THF, hexane, -40 deg C, 30 min 2: 1.) POCl3, 2.) 50percent aq. NaOH / 1.) reflux, 3 h, 2.) 30 deg C, 2 h, pH 8 View Scheme
Multi-step reaction with 2 steps 1: 1.) n-BuLi / 1.) THF, -40 deg C 2: POCl3 / Heating View Scheme
Multi-step reaction with 2 steps 1.1: n-butyllithium / tetrahydrofuran / 0.33 h / -30 - -10 °C / Inert atmosphere 1.2: 1 h / -10 °C / Inert atmosphere 2.1: trichlorophosphate / 4 h / 110 °C View Scheme
Multi-step reaction with 2 steps 1.1: n-butyllithium; sodium bromide / tetrahydrofuran / 0.5 h / 0 °C / Inert atmosphere 1.2: 2 h / Inert atmosphere 2.1: trichlorophosphate / 2.5 h / 80 °C View Scheme

1-Chloro-3-chloromethyl-benzene (620-20-2) → 3-[2-(3-chlorophenyl)ethyl]-2-pyridine-carbonitrile (31255-57-9)

Conditions	Yield
Multi-step reaction with 2 steps 1: 1.) n-BuLi / 1.) THF, -40 deg C 2: POCl3 / Heating View Scheme

3-[2-(3-Chlorophenyl)Ethyl]-1,1-Dimethylethyl)-2-Pyridine Carboxamide + 3-<2-(3-chlorophenyl)ethyl>-N-(1,1-dimethylethyl)-2-pyridinecarboxamide (107285-30-3) → 3-[2-(3-chlorophenyl)ethyl]-2-pyridine-carbonitrile (31255-57-9)

Conditions	Yield
With sodium hydroxide In water; isopropyl alcohol; trichlorophosphate	118 g (HPLC purity 95.7%)

C7H5ClMgN2 + 1-Chloro-3-chloromethyl-benzene (620-20-2) → 3-[2-(3-chlorophenyl)ethyl]-2-pyridine-carbonitrile (31255-57-9)

Conditions	Yield
With palladium 10% on activated carbon In tetrahydrofuran at 25 - 35℃; for 12h;	8.65 g

3-[2-(3-chlorophenyl)ethyl]-2-pyridine-carbonitrile (31255-57-9) → 3-(2-(3-chlorophenyl)ethanyl)pyridine-2-carboxylic acid

Conditions	Yield
Stage #1: 3-[2-(3-chlorophenyl)ethyl]-2-pyridine-carbonitrile With sulfuric acid; water at 120 - 122℃; for 10 - 12h; Stage #2: With sodium hydroxide In water at 90℃;	94.4%

3-[2-(3-chlorophenyl)ethyl]-2-pyridine-carbonitrile (31255-57-9) → 8-chloro-5,6-dihydro-11H-Benzo[5,6]cyclohepta[1,2-b]pyridin-11-one (31251-41-9)

Conditions	Yield
Stage #1: 3-[2-(3-chlorophenyl)ethyl]-2-pyridine-carbonitrile With trifluorormethanesulfonic acid at 60℃; for 1h; Stage #2: With hydrogenchloride In water at 20℃; for 1h; Heating / reflux;	94%
With PPA at 200℃;	45%
With PPA Heating;

4-chloro-1-methylpiperidine (5570-77-4) + 3-[2-(3-chlorophenyl)ethyl]-2-pyridine-carbonitrile (31255-57-9) → 1-(METHYL-4-PIPERIDINYL)[3-(2-(3-CHLORO-PHENYL)ETHYL)-2-PYRIDINYL]METHANONE HYDROCHLORIDE (119770-60-4)

Conditions	Yield
Stage #1: 4-chloro-1-methylpiperidine With iodine; magnesium In tetrahydrofuran; ethylene dibromide at 75℃; for 1h; Inert atmosphere; Stage #2: 3-[2-(3-chlorophenyl)ethyl]-2-pyridine-carbonitrile In tetrahydrofuran; ethylene dibromide at 40 - 50℃; for 1h; Inert atmosphere; Stage #3: With hydrogenchloride; water In tetrahydrofuran; ethylene dibromide at 20℃; for 1h; pH=< 2; Inert atmosphere;	83.3%

3-[2-(3-chlorophenyl)ethyl]-2-pyridine-carbonitrile (31255-57-9) + (1-methyl-4-piperidyl)magnesium chloride (63463-36-5) → 1-(METHYL-4-PIPERIDINYL)[3-(2-(3-CHLORO-PHENYL)ETHYL)-2-PYRIDINYL]METHANONE HYDROCHLORIDE (119770-60-4)

Conditions	Yield
In tetrahydrofuran at 30 - 60℃; for 1.5h;	48.6%

3-[2-(3-chlorophenyl)ethyl]-2-pyridine-carbonitrile (31255-57-9) + (1-methyl-4-piperidyl)magnesium chloride (63463-36-5) → {3-[2-(3-Chloro-phenyl)-ethyl]-pyridin-2-yl}-(1-methyl-piperidin-4-yl)-methanone (130642-50-1)

Conditions	Yield
With hydrogenchloride 1.) THF, reflux; Multistep reaction;
In pyridine

3-[2-(3-chlorophenyl)ethyl]-2-pyridine-carbonitrile (31255-57-9) + (1-methyl-4-piperidyl)magnesium chloride (63463-36-5) → C-{3-[2-(3-Chloro-phenyl)-ethyl]-pyridin-2-yl}-C-(1-methyl-piperidin-4-yl)-methyleneamine

Conditions	Yield
In tetrahydrofuran at 40 - 50℃; for 0.5h;

3-[2-(3-chlorophenyl)ethyl]-2-pyridine-carbonitrile (31255-57-9) → 10-chloro-11-(1-methyl-piperidin-4-yl)-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridine (244122-88-1)

Conditions	Yield
Multi-step reaction with 3 steps 1: pyridine 2: 99 percent / naBH4 / ethanol / 3 h 3: 3 percent / PPA / 3 h / 170 - 175 °C View Scheme

3-[2-(3-chlorophenyl)ethyl]-2-pyridine-carbonitrile (31255-57-9) → 8-chloro-11-(1-methyl-piperidin-4-yl)-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridine (170727-68-1)

Conditions	Yield
Multi-step reaction with 3 steps 1: pyridine 2: 99 percent / naBH4 / ethanol / 3 h 3: 5 percent / PPA / 3 h / 170 - 175 °C View Scheme

3-[2-(3-chlorophenyl)ethyl]-2-pyridine-carbonitrile (31255-57-9) → {3-[2-(3-chloro-phenyl)-ethyl]-pyridin-2-yl}-(1-methyl-piperidin-4-yl)-methanol (170727-67-0)

Conditions	Yield
Multi-step reaction with 2 steps 1: pyridine 2: 99 percent / naBH4 / ethanol / 3 h View Scheme

3-[2-(3-chlorophenyl)ethyl]-2-pyridine-carbonitrile (31255-57-9) → 1-[4-(10-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-piperidin-1-yl]-ethanone

Conditions	Yield
Multi-step reaction with 5 steps 1: pyridine 2: 99 percent / naBH4 / ethanol / 3 h 3: 3 percent / PPA / 3 h / 170 - 175 °C 4: NEt3 / benzene / 1.5 h / Heating 5: 1.) Zn dust, AcOH / 1.) 80-100 deg C, 1 h, 2.) CH2Cl2, reflux, 1 h View Scheme

3-[2-(3-chlorophenyl)ethyl]-2-pyridine-carbonitrile (31255-57-9) → 1-[4-(8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-piperidin-1-yl]-ethanone

Conditions	Yield
Multi-step reaction with 5 steps 1: pyridine 2: 99 percent / naBH4 / ethanol / 3 h 3: 5 percent / PPA / 3 h / 170 - 175 °C 4: NEt3 / benzene / 1.5 h / Heating 5: 1.) Zn dust, AcOH / 1.) 80-100 deg C, 1 h, 2.) CH2Cl2, reflux, 1 h View Scheme

3-[2-(3-chlorophenyl)ethyl]-2-pyridine-carbonitrile (31255-57-9) → 4-(8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-piperidine-1-carboxylic acid 2,2,2-trichloro-ethyl ester

Conditions	Yield
Multi-step reaction with 4 steps 1: pyridine 2: 99 percent / naBH4 / ethanol / 3 h 3: 5 percent / PPA / 3 h / 170 - 175 °C 4: NEt3 / benzene / 1.5 h / Heating View Scheme

3-[2-(3-chlorophenyl)ethyl]-2-pyridine-carbonitrile (31255-57-9) → 4-(10-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-piperidine-1-carboxylic acid 2,2,2-trichloro-ethyl ester

Conditions	Yield
Multi-step reaction with 4 steps 1: pyridine 2: 99 percent / naBH4 / ethanol / 3 h 3: 3 percent / PPA / 3 h / 170 - 175 °C 4: NEt3 / benzene / 1.5 h / Heating View Scheme

3-[2-(3-chlorophenyl)ethyl]-2-pyridine-carbonitrile (31255-57-9) → loratadine (79794-75-5)

Conditions	Yield
Multi-step reaction with 4 steps 1: tetrahydrofuran / 0.5 h / 40 - 50 °C 2: 2 N aq. HCl / tetrahydrofuran / 1 h / 25 - 30 °C 3: 20 g / BF3 / 4 h / 120 °C 4: 42.4 g / toluene / 1 h / 80 °C View Scheme
Multi-step reaction with 4 steps 1: tetrahydrofuran / 0.5 h / 40 - 50 °C 2: 2 N aq. HCl / tetrahydrofuran / 1 h / 25 - 30 °C 3: 91 percent / hydrofluoric acid, BF3 / -35 °C 4: 42.4 g / toluene / 1 h / 80 °C View Scheme
Multi-step reaction with 4 steps 1: tetrahydrofuran / 0.5 h / 40 - 50 °C 2: 2 N aq. HCl / tetrahydrofuran / 1 h / 25 - 30 °C 3: 44 percent / polyphosphoric acid (PPA) / 8 h / 190 °C 4: 42.4 g / toluene / 1 h / 80 °C View Scheme
Multi-step reaction with 3 steps 1: 2.) aq. HCl / 1.) THF, reflux 2: CF3SO3H / Heating 3: Et3N / toluene / Heating View Scheme
Multi-step reaction with 3 steps 1.1: magnesium; iodine / tetrahydrofuran; ethylene dibromide / 1 h / 75 °C / Inert atmosphere 1.2: 1 h / 40 - 50 °C / Inert atmosphere 1.3: 1 h / 20 °C / pH < 2 / Inert atmosphere 2.1: boric acid; sulfuric acid / chlorobenzene / 30 h / 80 - 90 °C 3.1: triethylamine / toluene / 2 h / 80 - 85 °C View Scheme

3-[2-(3-chlorophenyl)ethyl]-2-pyridine-carbonitrile (31255-57-9) → 8-chloro-11-(1-methyl-4-piperidinyl)-11H-benzo<5,6>cyclohepta<1,2-b>pyridine (119770-61-5)

Conditions	Yield
Multi-step reaction with 3 steps 1: tetrahydrofuran / 0.5 h / 40 - 50 °C 2: 2 N aq. HCl / tetrahydrofuran / 1 h / 25 - 30 °C 3: 0.85 g / polyphosphoric acid (PPA) / 8 h / 190 °C View Scheme

3-[2-(3-chlorophenyl)ethyl]-2-pyridine-carbonitrile (31255-57-9) → 8-chloro-7-(methylsulfonyl)-5-(4'-N-methylpiperidylidene)-4-aza-10,11-dihydro-5H-dibenzocycloheptene (119770-62-6)

Conditions	Yield
Multi-step reaction with 3 steps 1: tetrahydrofuran / 0.5 h / 40 - 50 °C 2: 2 N aq. HCl / tetrahydrofuran / 1 h / 25 - 30 °C 3: 0.3 g / BF3 / 4 h / 120 °C View Scheme

3-[2-(3-chlorophenyl)ethyl]-2-pyridine-carbonitrile (31255-57-9) → 1-(METHYL-4-PIPERIDINYL)[3-(2-(3-CHLORO-PHENYL)ETHYL)-2-PYRIDINYL]METHANONE HYDROCHLORIDE (119770-60-4)

Conditions	Yield
Multi-step reaction with 2 steps 1: tetrahydrofuran / 0.5 h / 40 - 50 °C 2: 2 N aq. HCl / tetrahydrofuran / 1 h / 25 - 30 °C View Scheme

3-[2-(3-chlorophenyl)ethyl]-2-pyridine-carbonitrile (31255-57-9) → N-methyldesloratadine (38092-89-6)

Conditions	Yield
Multi-step reaction with 3 steps 1: tetrahydrofuran / 0.5 h / 40 - 50 °C 2: 2 N aq. HCl / tetrahydrofuran / 1 h / 25 - 30 °C 3: 20 g / BF3 / 4 h / 120 °C View Scheme
Multi-step reaction with 3 steps 1: tetrahydrofuran / 0.5 h / 40 - 50 °C 2: 2 N aq. HCl / tetrahydrofuran / 1 h / 25 - 30 °C 3: 91 percent / hydrofluoric acid, BF3 / -35 °C View Scheme
Multi-step reaction with 3 steps 1: tetrahydrofuran / 0.5 h / 40 - 50 °C 2: 2 N aq. HCl / tetrahydrofuran / 1 h / 25 - 30 °C 3: 44 percent / polyphosphoric acid (PPA) / 8 h / 190 °C View Scheme
Multi-step reaction with 2 steps 1: 2.) aq. HCl / 1.) THF, reflux 2: CF3SO3H / Heating View Scheme
Multi-step reaction with 2 steps 1.1: magnesium; iodine / tetrahydrofuran; ethylene dibromide / 1 h / 75 °C / Inert atmosphere 1.2: 1 h / 40 - 50 °C / Inert atmosphere 1.3: 1 h / 20 °C / pH < 2 / Inert atmosphere 2.1: boric acid; sulfuric acid / chlorobenzene / 30 h / 80 - 90 °C View Scheme

3-[2-(3-chlorophenyl)ethyl]-2-pyridine-carbonitrile (31255-57-9) → {3-[8-Chloro-5,6-dihydro-benzo[5,6]cyclohepta[1,2-b]pyridin-(11Z)-ylidene]-propyl}-methyl-amine

Conditions	Yield
Multi-step reaction with 5 steps 1: PPA / Heating 2: tetrahydrofuran / -40 °C 3: H2SO4 4: Et3N / toluene / Heating 5: aq. KOH / Heating View Scheme

3-[2-(3-chlorophenyl)ethyl]-2-pyridine-carbonitrile (31255-57-9) → {3-[8-Chloro-5,6-dihydro-benzo[5,6]cyclohepta[1,2-b]pyridin-(11Z)-ylidene]-propyl}-dimethyl-amine

Conditions	Yield
Multi-step reaction with 3 steps 1: PPA / Heating 2: tetrahydrofuran / -40 °C 3: H2SO4 View Scheme

3-[2-(3-chlorophenyl)ethyl]-2-pyridine-carbonitrile (31255-57-9) → descarboethoxyloratadine (100643-71-8)

Conditions	Yield
Multi-step reaction with 4 steps 1: 2.) aq. HCl / 1.) THF, reflux 2: CF3SO3H / Heating 3: Et3N / toluene / Heating 4: aq. KOH / Heating View Scheme

3-[2-(3-chlorophenyl)ethyl]-2-pyridine-carbonitrile (31255-57-9) → 4-(8-Chloro-5,6-dihydro-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-cyclohexanone (130642-68-1)

Conditions	Yield
Multi-step reaction with 3 steps 1: PPA / Heating 2: diethyl ether; tetrahydrofuran 3: H2SO4 / H2O View Scheme

3-[2-(3-chlorophenyl)ethyl]-2-pyridine-carbonitrile (31255-57-9) → 4-(8-Chloro-5,6-dihydro-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-cyclohexanecarbaldehyde (130642-70-5)

Conditions	Yield
Multi-step reaction with 5 steps 1: PPA / Heating 2: diethyl ether; tetrahydrofuran 3: H2SO4 / H2O 4: tetrahydrofuran 5: H2SO4 / tetrahydrofuran; H2O View Scheme

3-[2-(3-chlorophenyl)ethyl]-2-pyridine-carbonitrile (31255-57-9) → N-formyldesloratadine (117810-61-4)

Conditions	Yield
Multi-step reaction with 5 steps 1: 2.) aq. HCl / 1.) THF, reflux 2: CF3SO3H / Heating 3: Et3N / toluene / Heating 4: aq. KOH / Heating 5: C5H5N / CH2Cl2 View Scheme

Upstream product

• 620-20-2 1-Chloro-3-chloromethyl-benzene 
• 31255-47-7 3-(3-chlorophenethyl)-pyridine N-oxide 
• 143-33-9 sodium cyanide 
• 107285-30-3 3-<2-(3-chlorophenyl)ethyl>-N-(1,1-dimethylethyl)-2-pyridinecarboxamide 
• 32998-95-1 N-tert-butyl-3-methylpyridine-2-carboxamide 
• 20970-75-6 2-cyano-3-methylpyridine 

Downstream Products

• 130642-50-1 {3-[2-(3-Chloro-phenyl)-ethyl]-pyridin-2-yl}-(1-methyl-piperidin-4-yl)-methanone 
• 31251-41-9 8-chloro-5,6-dihydro-11H-Benzo[5,6]cyclohepta[1,2-b]pyridin-11-one 
• 170727-67-0 {3-[2-(3-chloro-phenyl)-ethyl]-pyridin-2-yl}-(1-methyl-piperidin-4-yl)-methanol 
• 79794-75-5 loratadine 
• 119770-60-4 1-(METHYL-4-PIPERIDINYL)[3-(2-(3-CHLORO-PHENYL)ETHYL)-2-PYRIDINYL]METHANONE HYDROCHLORIDE 
• 38092-89-6 N-methyldesloratadine 
• 100643-71-8 descarboethoxyloratadine 
• 130642-68-1 4-(8-Chloro-5,6-dihydro-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-cyclohexanone 
• 130642-70-5 4-(8-Chloro-5,6-dihydro-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-cyclohexanecarbaldehyde 
• 117810-61-4 N-formyldesloratadine 
• 130642-69-2 8-Chloro-11-(4-methoxymethylene-cyclohexylidene)-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridine 
• 117796-52-8 N-acetyl desloratadine 
• 32998-95-1 N-tert-butyl-3-methylpyridine-2-carboxamide 

Relevant articles and documents

Preparation method of loratadine intermediate 3-[2-(3-chlorphenyl) ethyl]-2-pyridinecarbonitrile

The invention provides a preparation method as shown in a formula I and a preparation method of 3-[2-(3-chlorphenyl) ethyl]-2-pyridinecarbonitrile. The invention provides a novel method for preparing a loratadine intermediate.

Preparation method of loratadine

The invention provides a preparation method of loratadine. The method comprises the following steps: taking 2-cyano-3-methylpyridine as a raw material, and carrying out Ritter reaction, m-chlorobenzylchloride condensation, POCl3 deprotection group, Grignard reaction, cyclization and ethyl chloroformate substitution to obtain 4(8-chlorine-5, 6-dihydro-11H-benzo-[5, 6]cycloheptano[1, 2-b]pyridine-11-subunit)-1-piperidine carboxylic acid ethyl ester. According to the invention, a post-treatment process is innovated, and a new cyclization system is adopted to catalyze the reaction, so that the use of high-cost and high-toxicity strong acid is avoided, and a milder and more economical synthesis method is provided for industrial production.

Synthetic method for loratadine intermediate

The invention specifically relates to a synthetic method for a loratadine intermediate, belonging to the technical field of chemistry. The loratadine intermediate has a structure formula as described in the specification. The synthetic route of the synthetic method is as defined in the specification. The synthetic method is characterized by comprising the following steps: adding a compound 2 in a reaction solvent 1, then adding NCS (N-chlorosuccimide) or NBS (N-bromosuccimide) and an initiator in a reflux state and carrying out a reaction so as to obtain a compound 3; adding the compound 3 into a reaction solvent 2, then adding magnesium powder and iodine and carrying out a reaction under the protection of nitrogen so as to obtain a compound 4; and adding the compound 4 into a reaction solvent 3 and reacting the compound 4 with a compound 5 under palladium-carbon catalysis so as to synthesize a target product 1. The synthetic method provided by the invention avoids usage of hazardous reagents like n-butyllithium and does not need protection of a cyano group at first and then deprotection; and the compound 1 is a key loratadine intermediate, and simplification of synthesis of the intermediate is of important significance to synthesis of loratadine.