312638-96-3

Upstream product

• 158144-82-2 tert. butyl 4-aminomethyl-4-phenyl-piperidine-1-carboxylate 
• 158144-79-7 tert-butyl 4-cyano-4-phenylpiperidine-1-carboxylate 
• 24424-99-5 di-tert-butyl dicarbonate 
• 40481-13-8 4-phenyl-4-cyanopiperidine 
• 312638-88-3 4-cyclohexyl-4-azidomethylpiperidine-1-carboxylic acid tert-butyl ester 
• 312638-87-2 4-cyclohexyl-4-hydroxymethylpiperidine-1-carboxylic acid tert-butyl ester 
• 363192-22-7 4-cyclohexyl-4-formyl-piperidine-1-carboxylic acid tert-butyl ester 

Downstream Products

• 880544-10-5 4-[(3-chloro-propane-1-sulfonylamino)-methyl]-4-cyclohexyl-piperidine-1-carboxylic acid tert-butyl ester 
• 312638-97-4 N-[(1-Boc-4-cyclohexyl-4-piperidyl)methyl]methanesulfonamide 
• 852323-88-7 1-BOC-4-cyclohexyl-4-[(cyclohexylamino)methyl]piperidine 
• 455954-68-4 C₂₂H₃₉ClN₂O₃ 
• 880544-20-7 4-cyclohexyl-4-[(ethoxycarbonyl-isopropyl-amino)-methyl]-piperidine-1-carboxylic acid tert-butyl ester 
• 880544-11-6 4-cyclohexyl-4-(1,1-dioxo-1λ⁶-isothiazolidin-2-ylmethyl)-piperidine-1-carboxylic acid tert-butyl ester 
• 880544-18-3 4-cyclohexyl-4-[(isopropyl-methanesulfonyl-amino)-methyl]-piperidine-1-carboxylic acid tert-butyl ester 
• 880544-17-2 4-cyclohexyl-4-(isopropylamino-methyl)-piperidine-1-carboxylic acid tert-butyl ester 

Relevant academic research and scientific papers

THIAZOLYL COMPOUNDS USEFUL AS KINASE INHIBITORS

The invention provides compounds of formula (I) and pharmaceutically acceptable salts thereof. The formula I thiazolyl compounds inhibit tyrosine kinase activity thereby making them useful as anticancer agents and for the treatment of Alzheimer's disease

Optimization of a privileged structure leading to potent and selective human melanocortin subtype-4 receptor ligands

Design and synthesis of potent MC4 selective agonists based on cyclohexylpiperidine derived cyclic urea, oxazolidinones, and sulfonamide based privileged structures are disclosed.

MELANOCORTIN RECEPTOR AGONISTS

The present invention relates a compound of formula 1, and pharmaceutically acceptable salt, hydrate, solvate, or isomer thereof effective as agonist of melanocortin receptor, and an agonistic composition of melanocortin receptor comprising the same as active ingredient.

Substituted piperidines as melanocortin-4 receptor agonists

Certain novel substituted piperidine compounds are agonists of the human melanocortin receptor(s) and, in particular, are selective agonists of the human melanocortin-4 receptor (MC-4R). They are therefore useful for the treatment, control, or prevention of diseases and disorders responsive to the activation of MC-4R, such as obesity, diabetes, sexual dysfunction, including erectile dysfunction and female sexual dysfunction. Also provided are methods of treating sexual dysfunction with a compound that is a selective agonist of MC-4R over any other human melanocortin receptor.