312689-73-9

Upstream product

• 123-08-0 4-hydroxy-benzaldehyde 
• 123-25-1 succinic acid diethyl ester 

Downstream Products

• 312690-75-8 2-[1-{4-[2-(2-Cyclohexyl-5-methyl-oxazol-4-yl)-ethoxy]-phenyl}-meth-(E)-ylidene]-4-(3aR,7aS)-octahydro-isoindol-2-yl-4-oxo-butyric acid ethyl ester 
• 312690-76-9 2-[1-{4-[2-(5-Methyl-2-pyridin-4-yl-oxazol-4-yl)-ethoxy]-phenyl}-meth-(E)-ylidene]-4-(3aR,7aS)-octahydro-isoindol-2-yl-4-oxo-butyric acid ethyl ester 
• 312690-34-9 2-[1-{4-[2-(5-Methyl-2-phenyl-oxazol-4-yl)-ethoxy]-phenyl}-meth-(E)-ylidene]-4-(3aR,7aS)-octahydro-isoindol-2-yl-4-oxo-butyric acid ethyl ester 
• 312690-53-2 4-(3aR,7aS)-Octahydro-isoindol-2-yl-4-oxo-2-[1-{4-[3-(4-trifluoromethyl-phenyl)-propoxy]-phenyl}-meth-(E)-ylidene]-butyric acid ethyl ester 
• 312690-23-6 2-{4-[2-(5-Methyl-2-phenyl-oxazol-4-yl)-ethoxy]-benzyl}-4-(3aR,7aS)-octahydro-isoindol-2-yl-4-oxo-butyric acid ethyl ester 
• 312690-37-2 4-(3aR,7aS)-Octahydro-isoindol-2-yl-4-oxo-2-[1-{4-[2-(4-trifluoromethyl-phenyl)-ethoxy]-phenyl}-meth-(E)-ylidene]-butyric acid ethyl ester 
• 312690-39-4 4-(3aR,7aS)-Octahydro-isoindol-2-yl-4-oxo-2-[1-[4-(4-trifluoromethyl-benzyloxy)-phenyl]-meth-(E)-ylidene]-butyric acid ethyl ester 
• 312689-76-2 2-{4-[2-(5-Ethyl-pyridin-2-yl)-ethoxy]-benzyl}-4-(3aR,7aS)-octahydro-isoindol-2-yl-4-oxo-butyric acid ethyl ester 
• 312690-32-7 2-[1-{4-[2-(5-Ethyl-pyridin-2-yl)-ethoxy]-phenyl}-meth-(E)-ylidene]-4-(3aR,7aS)-octahydro-isoindol-2-yl-4-oxo-butyric acid ethyl ester 
• 312690-45-2 2-[1-{4-[2-(Methyl-pyridin-2-yl-amino)-ethoxy]-phenyl}-meth-(E)-ylidene]-4-(3aR,7aS)-octahydro-isoindol-2-yl-4-oxo-butyric acid ethyl ester 
• 312689-55-7 2-(4-Hydroxy-benzyl)-4-(3aR,7aS)-octahydro-isoindol-2-yl-4-oxo-butyric acid ethyl ester 
• 312689-54-6 2-(4-hydroxy-benzyl)-succinic acid 1-ethyl ester 

Relevant academic research and scientific papers

Hybridization of non-sulfonylurea insulin secretagogue and thiazolidinedione-derived insulin sensitizer

Hybrid compounds of non-sulfonylurea insulinotropic agents and thiazolidinedione-derived insulin-sensitizing agents were designed and synthesized. The benzylidenesuccinic acid derivative 24 was equal both to nateglinide in potency of insulin-releasing activity and to pioglitazone in insulin-sensitizing activity. (C) 2000 Elsevier Science Ltd.