312689-76-2

Upstream product

• 1470-99-1 cis-hexahydroisoindoline 
• 123-25-1 succinic acid diethyl ester 
• 123-08-0 4-hydroxy-benzaldehyde 
• 144809-27-8 toluene-4-sulfonic acid 2-(5-ethylpyridin-2-yl)ethyl ester 
• 312689-55-7 2-(4-Hydroxy-benzyl)-4-(3aR,7aS)-octahydro-isoindol-2-yl-4-oxo-butyric acid ethyl ester 
• 312689-73-9 2-[1-(4-Hydroxy-phenyl)-meth-(E)-ylidene]-succinic acid 1-ethyl ester 
• 312689-54-6 2-(4-hydroxy-benzyl)-succinic acid 1-ethyl ester 

Relevant academic research and scientific papers

Hybridization of non-sulfonylurea insulin secretagogue and thiazolidinedione-derived insulin sensitizer

Hybrid compounds of non-sulfonylurea insulinotropic agents and thiazolidinedione-derived insulin-sensitizing agents were designed and synthesized. The benzylidenesuccinic acid derivative 24 was equal both to nateglinide in potency of insulin-releasing activity and to pioglitazone in insulin-sensitizing activity. (C) 2000 Elsevier Science Ltd.