799293-73-5

Usage

Uses

Used in Pharmaceutical Development:
3-bromofuro[3,2-c]pyridin-4-amine is utilized as a key intermediate in the synthesis of new pharmaceutical drugs. Its unique structure allows for the creation of compounds that can target specific biological pathways, making it a promising candidate for the development of medications addressing a range of diseases, especially those related to the central nervous system.
Used in Medicinal Chemistry Research:
In the field of medicinal chemistry, 3-bromofuro[3,2-c]pyridin-4-amine serves as a valuable building block for the design and synthesis of novel compounds with potential therapeutic applications. Its presence in a molecule can influence pharmacokinetic and pharmacodynamic properties, contributing to the discovery of more effective and safer drugs.
Used in Drug Discovery:
3-bromofuro[3,2-c]pyridin-4-amine is employed in drug discovery processes to explore its potential as a lead compound for the treatment of various diseases. Its chemical properties and structural features make it a versatile component in the creation of new drug candidates that can be optimized through further chemical modifications.
Further studies and research are essential to fully understand the capabilities and applications of 3-bromofuro[3,2-c]pyridin-4-amine in drug development and medicinal chemistry, ensuring its potential is harnessed to contribute to advancements in healthcare and therapeutic interventions.

Upstream product

• 31270-80-1 4-chlorofuro[3,2-c]pyridine 
• 29080-01-1 β-(2-Furan)-vinylisocyanat 
• 539-47-9 3-(2-furyl)acrylic acid 
• 26956-43-4 5H-furo[3,2-c]pyridin-4-one 
• 59898-36-1 (E)-3-Furan-2-yl-acryloyl azide 
• 98-01-1 furfural 
• 220939-72-0 4-chloro-3-bromofuro<3,2-c>pyridine 

Downstream Products

• 799293-74-6 4-amino-3-(4-aminophenyl)-furo[3,2-c]pyridine 
• 799293-76-8 4-amino-3-(4-((2-fluoro-5-(trifluoromethyl)aminocarbonylamino)phenyl))-furo[3,2-c]pyridine 
• 799293-78-0 4-amino-3-(4-((2-fluoro-5-(trifluoromethyl)aminocarbonylamino)phenyl))-7-bromo-furo[3,2-c]pyridine 
• 1571111-34-6 6-(4-aminofuro[3,2-c]pyridin-3-yl)-N-phenyl-1-naphthalenecarboxamide 

Relevant academic research and scientific papers

N-(SUBSTITUTED-PHENYL)-SULFONAMIDE DERIVATIVES AS KINASE INHIBITORS

The invention relates to N-(substituted-phenyl)-sulfonamide compounds, which are extremely useful as inhibitors of protein kinases (e.g. PERK kinase) and accordingly can be used for the treatment of cell proliferative disorders, such as cancer, or diseases associated with activated unfolded protein response pathways, such as Alzheimer's disease. The present invention also provides methods for preparing these compounds, pharmaceutical compositions comprising these compounds, and methods of treating diseases utilizing pharmaceutical compositions comprising these compounds.

NAPHTHYLAMIDE COMPOUND, PREPARATION METHOD AND USE THEREOF

The present invention relates to a naphthylamide compound of the structure as represented by formula (I), medicinal salts, prodrugs and hydrates or solvates thereof, and also relates to a method of preparing the compounds, pharmaceutical compositions comp

Discovery of a new series of naphthamides as potent VEGFR-2 kinase inhibitors

Inhibition of VEGFR-2 signaling pathway has already become one of the most promising approaches for the treatment of cancer. In this study, we describe the design, synthesis, and biological evaluation of a new series of naphthamides as potent inhibitors of VEGFR-2. Among these compounds, 14c exhibited high VEGFR-2 inhibitory potency in both enzymatic and HUVEC cellular proliferation assays, with IC50 values of 1.5 and 0.9 nM, respectively. Kinase selectivity profiling revealed that 14c was a multitargeted inhibitor, and it also exhibited good potency against VEGFR-1, PDGFR-β, and RET. Furthermore, 14c effectively blocked tube formation of HUVEC at nanomolar level. Overall, 14c might be a promising candidate for the treatment of cancer.

Design and effective synthesis of novel templates, 3,7-diphenyl-4-amino-thieno and furo-[3,2-c]pyridines as protein kinase inhibitors and in vitro evaluation targeting angiogenetic kinases

A novel class of 3,7-diphenyl-4-amino-thieno and furo[3,2-c]pyridine has been designed based on pharmacophore models of ATP competitive kinase inhibitors. Versatile synthetic methods via double Suzuki coupling to explore SAR have been established and potent inhibitors against angiogenetic targets, VEGFR2, Tie-2, and EphB4, have been successfully discovered.

Thienopyridine and furopyridine kinase inhibitors

Compounds having the formula are useful for inhibiting protein tyrosine kinases. The present invention also discloses methods of making the compounds, compositions containing the compounds, and methods of treatment using the compounds.

NOVEL CHEMICAL COMPOUNDS

This invention relates to newly identified compounds for treating and preventing tumors ans cancers, and methods for treating proliferative diseases associated with the imbalance or inappropriate activity of tyrosine kinases implicated in proliferative diseases.