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Usage

Uses

Used in Pharmaceutical Industry:
DMICA is used as a building block for the synthesis of various pharmaceuticals and bioactive compounds. Its unique chemical structure and properties make it a valuable starting material for the development of new drug molecules.
Used in Research Settings:
DMICA is used as a research compound to study its anti-inflammatory and antifungal properties. It is also utilized in cancer research to explore its potential applications in the development of novel therapeutic agents.
Used in Drug Development:
DMICA is employed as a starting material for the development of new drug molecules. Its potential as a building block in the synthesis of pharmaceuticals and bioactive compounds makes it a valuable asset in drug discovery and development processes.

Upstream product

• 146432-92-0 ethyl 4,7-dimethoxy-1H-indole-2-carboxylate 

Downstream Products

• 23876-39-3 4,7-dimethoxylindole 

Relevant academic research and scientific papers

Synthesis and antiprotozoal evaluation of benzothiazolopyrroloquinoxalinones, analogues of kuanoniamine A

Boc-aminoethylindoloquinone 8, a key intermediate for the building of pentacyclic quinoneimines, analogues of kuanoniamine A, was synthesized by alkylation of 4,7-dimethoxyindole 3 with 1,2-dibromoethane followed by transformation into azide, reduction of the latter with trimethylphosphine in the presence of 2-(tert-butoxycarbonyloximino)-2-phenylacetonitrile and oxydative demethylation of the Boc-amine 6 with silver(II) oxide. Quinone 8 was then treated in situ with the thiazole o-quinodimethane 10 to afford a regioisomeric mixture of the tetracyclic quinones 11. Treatment of the mixture with trifluoroacetic acid and molecular sieves 4-A provided the corresponding quinoneimines 12. Separation of the regioisomers was performed by preparative thin-layer chromatography on silica gel. The structural assignment was made by 2D 1H-13C HMBC correlations performed on the less polar regioisomer 12b. In vitro anti-leishmanial assays showed that the tested compounds possess a good potency towards two Leishmania sp. as well as against a virulent strain of Toxoplasma gondii and without any cytotoxicity against THP-1 cells.