312734-34-2 Usage
Description
N-(2-FLUORO-PHENYL)-3,4-DIMETHOXY-BENZAMIDE is a chemical compound with the molecular formula C15H14FNO3. It is a benzamide derivative featuring a fluorine-substituted phenyl group and two methoxy substituents on the benzene ring. N-(2-FLUORO-PHENYL)-3,4-DIMETHOXY-BENZAMIDE holds potential in medicinal chemistry and pharmaceutical research due to its unique structural features and possible biological activities. The specific properties and applications of N-(2-FLUORO-PHENYL)-3,4-DIMETHOXY-BENZAMIDE can vary depending on the context and the particular research or application it is employed in.
Uses
Used in Medicinal Chemistry:
N-(2-FLUORO-PHENYL)-3,4-DIMETHOXY-BENZAMIDE is used as a chemical intermediate for the synthesis of various pharmaceutical compounds. Its unique structure allows it to be a promising candidate in the development of new drugs with specific therapeutic targets.
Used in Pharmaceutical Research:
In pharmaceutical research, N-(2-FLUORO-PHENYL)-3,4-DIMETHOXY-BENZAMIDE is utilized for investigating its potential biological activities. N-(2-FLUORO-PHENYL)-3,4-DIMETHOXY-BENZAMIDE's structural elements, including the fluorine substitution and methoxy groups, may contribute to its interaction with biological targets, making it a valuable tool for studying molecular mechanisms and developing therapeutic agents.
Used in Drug Design and Development:
N-(2-FLUORO-PHENYL)-3,4-DIMETHOXY-BENZAMIDE is employed as a lead compound in drug design and development processes. Its structural features can be optimized and modified to enhance its pharmacological properties, potentially leading to the creation of novel and effective medications for various diseases and conditions.
Used in Biochemical Studies:
N-(2-FLUORO-PHENYL)-3,4-DIMETHOXY-BENZAMIDE is also used in biochemical studies to understand its interactions with enzymes, receptors, or other biological molecules. Such studies can provide insights into the compound's mechanism of action and its potential use in treating specific medical conditions.
Check Digit Verification of cas no
The CAS Registry Mumber 312734-34-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 3,1,2,7,3 and 4 respectively; the second part has 2 digits, 3 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 312734-34:
(8*3)+(7*1)+(6*2)+(5*7)+(4*3)+(3*4)+(2*3)+(1*4)=112
112 % 10 = 2
So 312734-34-2 is a valid CAS Registry Number.
312734-34-2Relevant articles and documents
Exogenous Photosensitizer-, Metal-, and Base-Free Visible-Light-Promoted C-H Thiolation via Reverse Hydrogen Atom Transfer
Xu, Ze-Ming,Li, Hong-Xi,Young, David James,Zhu, Da-Liang,Li, Hai-Yan,Lang, Jian-Ping
supporting information, p. 237 - 241 (2019/01/10)
Visible-light-driven, intramolecular C(sp2)-H thiolation has been achieved without addition of a photosensitizer, metal catalyst, or base. This reaction induces the cyclization of thiobenzanilides to benzothiazoles. The substrate absorbs visible light, and its excited state undergoes a reverse hydrogen-atom transfer (RHAT) with 2,2,6,6-tetramethylpiperidine N-oxyl to form a sulfur radical. The addition of the sulfur radical to the benzene ring gives an aryl radical, which then rearomatizes to benzothiazole via RHAT.
Antitumor benzothiazoles. 26.1 2-(3,4-dimethoxyphenyl)-5- fluorobenzothiazole (GW 610, NSC 721648), a simple fluorinated 2-arylbenzothiazole, shows potent and selective inhibitory activity against lung, colon, and breast cancer cell lines
Mortimer, Catriona G.,Wells, Geoffrey,Crochard, Jean-Philippe,Stone, Erica L.,Bradshaw, Tracey D.,Stevens, Malcolm F. G.,Westwell, Andrew D.
, p. 179 - 185 (2007/10/03)
A series of new 2-phenylbenzothiazoles has been synthesized on the basis of the discovery of the potent and selective in vitro antitumor properties of 2-(3,4-dimethoxyphenyl)-5-fluorobenzothiazole (8n; GW 610, NSC 721648). Synthesis of analogues substituted in the benzothiazole ring was achieved via the reaction of o-aminothiophenol disulfides with substituted benzaldehydes under reducing conditions. Compounds were evaluated in vitro in four human cancer cell lines, and compound 8n was found to possess exquisitely potent antiproliferative activity (GI50 0.1 nM for MCF-7 and MDA 468). Potent and selective activity was also observed in the NCI 60 human cancer cell line panel. Structure-activity relationships established that the compound 8n stands on a pinnacle of potent activity, with most structural variations having a deactivating in vitro effect. Mechanistically, this new series of agents contrasts with the previously reported 2-(4-aminophenyl)benzothiazoles; compound 8n is not reliant on induction of CYP1A1 expression for antitumor activity.
