312746-72-8

Usage

Uses

Used in Pharmaceutical Synthesis:
1H-Indazole-7-carbaldehyde is used as a key intermediate in the development of new drug molecules, leveraging its unique structure to create novel therapeutic agents. Its reactivity allows for the formation of various chemical bonds, facilitating the synthesis of a wide range of pharmaceutical compounds.
Used in Organic Synthesis:
As a building block in organic synthesis, 1H-Indazole-7-carbaldehyde is utilized for the creation of complex organic molecules. Its presence in the synthesis process can lead to the development of new chemical entities with potential applications across various industries.
Used in Material Science:
1H-Indazole-7-carbaldehyde has potential applications in material science, where its unique properties can contribute to the development of new materials with specific characteristics. Its use in this field is still under exploration, but it holds promise for future advancements.
Used in Chemical Process Research and Development:
In the realm of chemical process research and development, 1H-Indazole-7-carbaldehyde serves as a valuable compound for investigating new chemical reactions and processes. Its involvement in these studies can lead to the discovery of more efficient and effective methods for chemical synthesis and production.

InChI:InChI=1/C8H6N2O/c11-5-7-3-1-2-6-4-9-10-8(6)7/h1-5H,(H,9,10)

Upstream product

• 677304-69-7 1H-indazole-7-carboxylic acid 
• 1092961-09-5 (1H-indazol-7-yl)methanol 
• 755752-82-0 1H-indazole-7-carboxylic acid methyl ester 
• 22223-49-0 methyl 2-amino-3-methylbenzoate 
• 4389-45-1 3-methylantranilic acid 
• 1127-59-9 7-methyl-1H-indole-2,3-dione 
• 1132-03-2 2-(hydroxyimino)-N-(2-methylphenyl)acetamide 
• 95-53-4 o-toluidine 

Downstream Products

• 944899-03-0 3-iodo-1H-indazole-7-carbaldehyde 

Relevant academic research and scientific papers

BICYCLIC COMPOUNDS

Provided herein are compounds and pharmaceutical compositions comprising said compounds that are useful for treating cancers. Specific cancers include those that are mediated by YAP/TAZ or those that are modulated by the interaction between YAP/TAZ and TEAD.

Asymmetric Synthesis of Fused Polycyclic Indazoles through Aminocatalyzed Aza-Michael Addition/Intramolecular Cyclization

The first example of an asymmetric aminocatalyzed aza-Michael addition of 1H-indazole derivatives to α,β-unsaturated aldehydes is described. The iminium/enamine cascade process lies at the heart of our strategy, leading to enantioenriched fused polycyclic indazole architectures. Variations on both the α,β-unsaturated aldehydes and the indazole-7-carbaldehyde heterocycles were studied in order to broaden the scope of the transformation in synthetically interesting directions. The fused polycyclic indazoles exhibit fluorescence properties and can undergo synthetic transformations.

Synthesis and pharmacological evaluation of N-benzyl substituted 4-bromo-2,5-dimethoxyphenethylamines as 5-HT2A/2C partial agonists

N-Benzyl substitution of phenethylamine 5-HT2A receptor agonists has dramatic effects on binding affinity, receptor selectivity and agonist activity. In this paper we examine how affinity for the 5-HT2A/2C receptors are influenced by N-benzyl substitution of 4-bromo-2,5-dimethoxyphenethylamine derivatives. Special attention is given to the 2′ and 3′-position of the N-benzyl as such compounds are known to be very potent. We found that substitutions in these positions are generally well tolerated. The 2′-position was further examined using a range of substituents to probe the hydrogen bonding requirements for optimal affinity and selectivity, and it was found that small changes in the ligands in this area had a profound effect on their affinities. Furthermore, two ligands that lack a 2′-benzyl substituent were also found to have high affinity contradicting previous held notions. Several high-affinity ligands were identified and assayed for functional activity at the 5-HT2A and 5-HT2C receptor, and they were generally found to be less efficacious agonists than previously reported N-benzyl phenethylamines.