1132-03-2

Basic information

• Product Name: 2-(hydroxyimino)-N-(2-methylphenyl)acetamide
• Synonyms: 2-(hydroxyimino)-N-(2-methylphenyl)acetamide;Nsc20557;(2E)-2-(Hydroxyimino)-N-(2-methylphenyl)acetamide;AcetaMide, 2-(hydroxyiMino)-N-(2-Methylphenyl)-
• CAS NO: 1132-03-2
• Molecular Formula: C₉H₁₀N₂O₂
• Molecular Weight: 178.1879
• EINECS: 214-472-2
• Mol File: 1132-03-2.mol
• Article Data: 18

Chemical Properties

• Appearance: /
• Density: 1.17g/cm³
• Refractive Index: 1.559
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 2-(hydroxyimino)-N-(2-methylphenyl)acetamide(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(hydroxyimino)-N-(2-methylphenyl)acetamide(1132-03-2)
• EPA Substance Registry System: 2-(hydroxyimino)-N-(2-methylphenyl)acetamide(1132-03-2)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 1132-03-2(Hazardous Substances Data)

Usage

General Description

2-(hydroxyimino)-N-(2-methylphenyl)acetamide is a chemical compound that has a molecular formula C10H12N2O2. It is an organic compound containing an oxime functional group and an acetamide functional group. 2-(hydroxyimino)-N-(2-methylphenyl)acetamide is a light yellow solid and is commonly used in organic synthesis and pharmaceutical research. It is also known for its potential biological activity and is used as an intermediate in the preparation of various pharmaceutical and agrochemical compounds. Additionally, it has been studied for its potential antimicrobial and antioxidant properties, making it a compound of interest in the field of medicinal chemistry.

InChI:InChI=1/C9H10N2O2/c1-7-4-2-3-5-8(7)11-9(12)6-10-13/h2-6,13H,1H3,(H,11,12)/b10-6+

Upstream product

• 75-87-6 chloral 
• 95-53-4 o-toluidine 
• 515-83-3 chloral ethyl hemiacetal 
• 302-17-0 chloral hydrate 

Downstream Products

• 4389-45-1 3-methylantranilic acid 
• 22223-49-0 methyl 2-amino-3-methylbenzoate 
• 755752-82-0 1H-indazole-7-carboxylic acid methyl ester 
• 1092961-09-5 (1H-indazol-7-yl)methanol 
• 312746-72-8 1-H-indazole-7-carbaldehyde 
• 13208-93-0 N-(4-chloro-2-methylphenyl)-2-(hydroxyimino)acetamide 
• 1217506-81-4 3-(allyloxy)-1-(3-chloropyridin-2-yl)-N-(2-(cyclopropylcarbamoyl)-6-methylphenyl)-1H-pyrazole-5-carboxamide 
• 1217506-80-3 3-(allyloxy)-1-(3-chloropyridin-2-yl)-N-(2-(isopropylcarbamoyl)-6-methylphenyl)-1H-pyrazole-5-carboxamide 
• 1217506-79-0 3-(allyloxy)-1-(3-chloropyridin-2-yl)-N-(2-methyl-6-(propylcarbamoyl)phenyl)-1H-pyrazole-5-carboxamide 
• 1217506-73-4 3-(allyloxy)-N-(4-chloro-2-(cyclohexylcarbamoyl)-6-methylphenyl)-1-(3-chloropyridin-2-yl)-1H-pyrazole-5-carboxamide 
• 1217506-72-3 3-(allyloxy)-N-(4-chloro-2-(isobutylcarbamoyl)-6-methylphenyl)-1-(3-chloropyridin-2-yl)-1H-pyrazole-5-carboxamide 
• 1217506-71-2 3-(allyloxy)-N-(2-(butylcarbamoyl)-4-chloro-6-methylphenyl)-1-(3-chloropyridin-2-yl)-1H-pyrazole-5-carboxamide 
• 1217506-70-1 3-(allyloxy)-N-(4-chloro-2-methyl-6-(propylcarbamoyl)phenyl)-1-(3-chloropyridin-2-yl)-1H-pyrazole-5-carboxamide 
• 500008-45-7 rynaxypyr 

Relevant articles and documents

Modified synthetic route to 2-hydroxyimino-N-arylacetamides

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Synthesis process of 2-amino-5-chloro-3-methylbenzoic acid intermediate 2-(hydroxyimino)-N-(2-methylphenyl)acetamide

The invention discloses a novel process for synthesizing a 2-amino-5-chloro-3-methylbenzoic acid intermediate, namely 2-(hydroxyimino)-N-(2-methylphenyl)acetamide. According to the process, o-aminotoluene is used as a main starting raw material, and synthesis of 2-(hydroxyimino)-N-(2-methylphenyl)acetamide is realized through two steps including amino acetylation and oximation. Compared with the prior art, the process of the invention has the advantages that product yield reaches 97% or above, the generation of waste salt sodium chloride and sodium sulfate is reduced by three times or above, intermediate raw materials are low in price, process is simple, cost is reduced, and environmental and economic benefits are improved.

Design and development of Isatin-triazole hydrazones as potential inhibitors of microtubule affinity-regulating kinase 4 for the therapeutic management of cell proliferation and metastasis

Microtubule affinity-regulating kinase 4 (MARK4) is a potential drug target as the same is found to be over expressed in several types of cancers. In search of effective MARK4 inhibitors, we have synthesized and characterized Isatin-triazole hydrazones (9a-i) and evaluated their inhibitory potential. Of all the compounds, 9g showed better binding affinity and enzyme inhibition potential in sub micromolar range. Human serum albumin (HSA) binding assay suggested an easy transportation of 9g in blood stream due to its binding affinity. In vitro anticancer studies performed on MCF-7, MDA-MB-435s and HepG2 cells using 9g showed inhibition of cell proliferation and cell migration. Further, 9g induces apoptosis in these cancerous cells, with IC50 values of 6.22, 9.94 and 8.14 μM, respectively. Putatively, 9g seems to cause oxidative stress resulting in apoptosis. Functional assay of 9g with a panel of 26 kinases showed MARK4 specific profile. In conclusion, 9g seems to possess an effective inhibitory potential towards MARK4 adding an additional repertoire to anticancer therapeutics.