312759-87-8Relevant academic research and scientific papers
Application of organolithium and related reagents in synthesis, part 31: Effective conversion of 3-arylphthalides into 2-(1-aryl-3-oxo-4- alkoxycarbonylbutyl) benzoic acids
Bieniek, Adam,Kulikiewicz, Krystyna K.,Bartczak, Monika M.
, p. 3249 - 3259 (2007/10/03)
A convenient three-step protocol preparation of the ortho-alkylated (longchain substituent with terminal methylcarbonyl or acetoacetate moiety) aromatic carboxylic acids 15 or 16 from benzoic acids anilides 10 was developed, which exploited the reductive
Application of organolithium and related reagents in synthesis, Part 24.1 Synthetic strategies based on aromatic metallation. A concise regiospecific conversion of benzoic acids into 2-(1-aryl-2-methoxycarbonylethyl)benzoic acids
Epsztajn,Bieniek,Kowalska,Kulikiewicz
, p. 1603 - 1607 (2007/10/03)
The synthesis of the 3-arylphthalides 3 via metallation (BuLi) of the benzanilides 1 and subsequent reaction of the generated bis-lithiated anilides 2 with aromatic aldehydes is described. Conversion of 3 into the corresponding 2-(1-aryl-2-methoxycarbonylethyl)benzoic acids 4 by treatment with 1-methoxy-1-trimethylosiloxyethene in the presence of titanium tetrachloride, as a way of regiospecific transformation of benzoic acids, is also described.
