312946-37-5

Usage

Uses

LDN 27219 is a transglutaminase inhibitor.

Upstream product

• 98-86-2 acetophenone 
• 142465-09-6 2-mercapto-3,5-diphenyl-3H-thieno[2,3-d]pyrimidin-4-one 
• 103-72-0 phenyl isothiocyanate 
• 132605-18-6 4-Phenyl-2-(3-phenyl-thioureido)-thiophene-3-carboxylic acid ethyl ester 
• 4815-36-5 ethyl 2-amino-4-phenyl-thiophene-3-carboxylate 
• 312946-35-3 (4-oxo-3,5-diphenyl-3,4-dihydrothieno[2,3-d]pyrimidin-2-ylsulfanyl)acetic acid ethyl ester 

Relevant academic research and scientific papers

SUBSTITUED 3,4-DIHYDROTHIENO [2,3-D] PYRMIDINES AS TISSUE TRANSGLUTAMINASE INHIBITORS

The present invention provides novel compounds and methods useful for treating transglutaminase associated disorders such as celiac spru, Alzheimer's disease and Huntington's disease. Certain compounds of the invention are tissue transglutaminase inhibito

Structure-activity relationship study of novel tissue transglutaminase inhibitors

Thieno[2,3-d]pyrimidin-4-one acylhydrazide derivatives were discovered as moderately potent inhibitors of TGase 2 (tissue transglutaminase) utilizing a fluorescence-based assay that measured TGase 2 catalyzed incorporation of the dansylated Lys derivative