31295-66-6 Usage
General Description
4-IODO-5-METHYL-3-PHENYLISOXAZOLE is a chemical compound with the molecular formula C10H8IN2O. It is an isoxazole derivative, which contains a five-membered heterocyclic ring with oxygen and nitrogen atoms. 4-IODO-5-METHYL-3-PHENYLISOXAZOLE has a methyl group at position 5 and a phenyl group at position 3, with an iodine atom attached to the carbon at position 4. 4-IODO-5-METHYL-3-PHENYLISOXAZOLE has potential pharmaceutical applications, particularly in the field of medicinal chemistry, due to its ability to act as a building block for the synthesis of biologically active molecules. Additionally, it has been studied for its antimicrobial and anticancer properties, making it a subject of interest in the development of new drugs and treatments.
Check Digit Verification of cas no
The CAS Registry Mumber 31295-66-6 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 3,1,2,9 and 5 respectively; the second part has 2 digits, 6 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 31295-66:
(7*3)+(6*1)+(5*2)+(4*9)+(3*5)+(2*6)+(1*6)=106
106 % 10 = 6
So 31295-66-6 is a valid CAS Registry Number.
InChI:InChI=1/C10H8INO/c1-7-9(11)10(12-13-7)8-5-3-2-4-6-8/h2-6H,1H3
31295-66-6Relevant articles and documents
Preparation method of parecoxib sodium intermediate 5-methyl-3,4-diphenyl isoxazole
-
Paragraph 0032; 0035-0036, (2018/07/06)
The invention relates to a preparation method of parecoxib sodium intermediate 5-methyl-3,4-diphenyl isoxazole. The preparation method comprises the following steps: step one, taking phenyl propinyl ketone as a starting material, firstly, carrying out condensation with methanol aminated hydrochloride to generate Z-type 1-phenyl-1-propinyl-3-methyl-oxime; step two, carrying out a cycloaddition reaction on the Z-type 1-phenyl-1-propinyl-3-methyl-oxime and iodine chloride to generate 3-phenyl-4-iodo-5-methyl isoxazole; and step three, carrying out a substitution reaction on the 3-phenyl-4-iodo-5-methyl isoxazole and phenylboronic acid to generate 5-methyl-3,4-diphenyl isoxazole.
Synthesis of isoxazoles via electrophilic cyclization
Waldo, Jesse P.,Larock, Richard C.
, p. 5203 - 5205 (2007/10/03)
(Chemical Equation Presented) A variety of 3,5-disubstituted 4-halo(seleno)isoxazoles are readily prepared in good to excellent yields under mild reaction conditions by the reaction of 2-alkyn-1-one O-methyl oximes with ICI, I2, Br2,
