31310-22-2

Basic information

• Product Name: ethyl 3-methylbenzo[b]thiophene-2-carboxylate
• Synonyms: ethyl 3-methylbenzo[b]thiophene-2-carboxylate
• CAS NO: 31310-22-2
• Molecular Weight: 220.292
• Mol File: 31310-22-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: ethyl 3-methylbenzo[b]thiophene-2-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 3-methylbenzo[b]thiophene-2-carboxylate(31310-22-2)
• EPA Substance Registry System: ethyl 3-methylbenzo[b]thiophene-2-carboxylate(31310-22-2)

Safety Data

• Hazardous Substances Data: 31310-22-2(Hazardous Substances Data)

Upstream product

• 2142-69-0 2-bromophenyl methyl ketone 
• 623-51-8 ethyl 2-sulfanylacetate 

Downstream Products

• 175135-07-6 benzo[b]thiophene-2-carboxylic acid hydrazide 

Relevant articles and documents

ETUDE DES REACTIONS DE SRN1-PARTIE 10 ACTION DE SULFANIONS SUR LES HALOGENURES D'ARYLE FONCTIONNALISES. SYNTHESE DIRECTE DE BENZOTHIOPHENES ET THIENOPYRIDINES

Functionalized aromatic halides Ar1XY (Ar1=C6H4, Y=OCH3,CONH2,CN,COCH3,CHO,COC6H5) undergo SRN1 reactions with sulphur anions -SR, either simple (R=C2H5,CH2C6H5) or functionalized (R=(CH2)2OH,(CH2)2CO2Et,CH2CO2Et).Products Ar1YS- formed from the fragmentation of the radical anion Ar1YSR- are related to the redox potential of the aryl moiety Ar1Y and with the energy of the bond S-R.In the heterocyclic series (Ar2=pyridine, Ar3=quinoline) a similar relationship appears but a competitive SN(AR) reaction occurs for pyridine substrates bearing an electron withdrawing group.A direct synthesis of benzothiophen via SRN1 reaction and an improved synthesis of thienopyridines based on the SN(Ar) reaction are reported.