31321-68-3

Usage

Uses

Used in Pharmaceutical Industry:
(R)-Piperazine-2-carboxylic acid is used as a building block for the synthesis of various drug molecules, contributing to the development of novel therapeutic agents.
(R)-Piperazine-2-carboxylic acid is used as a precursor in the design of new pharmaceuticals for its potential role in modulating neurotransmitter receptors, which can lead to the creation of drugs with targeted effects on the nervous system.
Used in Drug Development:
(R)-Piperazine-2-carboxylic acid is utilized in the research and development of new medications due to its potential biological activities, including its role in modulating neurotransmitter receptors, making it a promising candidate for further exploration in drug discovery processes.

InChI:InChI=1/C5H10N2O2/c8-5(9)4-3-6-1-2-7-4/h4,6-7H,1-3H2,(H,8,9)/t4-/m1/s1

Upstream product

• 84501-64-4 2-aminocarbonylpiperazine 
• 138681-31-9 R-(+)-Piperazine-2-carboxamide 
• 98-96-4 pyrazinamide 

Downstream Products

• 256446-66-9 (R)-1,4-bis((benzyloxy)carbonyl)piperazine-2-carboxylic acid 
• 173774-48-6 (R)-piperazine-1,2,4-tricarboxylic acid 1,4-di-tert-butyl ester 
• 1187364-81-3 (2R)-N-((R)-1-(4-(4-methoxybenzyl)-5-phenethyl-4H-1,2,4-triazol-3-yl)-2-(1H-indol-3-yl)ethyl)piperazine-2-carboxamide 

Relevant academic research and scientific papers

Preparation of (S)-piperazine-2-carboxylic acid, (R)-piperazine-2-carboxylic acid, and (S)-piperidine-2-carboxylic acid by kinetic resolution of the corresponding racemic carboxamides with stereoselective amidases in whole bacterial cells

Whole bacterial cells containing stereospecific amidases were used for the kinetic resolution of racemic piperazine-2-carboxamide and piperidine-2-carboxamide to (S)- and (R)-piperazine-2-carboxylic acid, and (S)-piperidine-2-carboxylic acid, respectively. (S)-Piperazinecarboxylic acid dihydrochloride produced with the biocatalysts Klebsiella terrigena DSM 9174 had an ee value of 99.4% (41% yield), and the ee value of (R)-piperazinecarboxylic acid dihydrochloride obtained with Burkholderia sp. DSM 9925 was 99.0% (22% yield). Using Pseudomonas fluorescens DSM 9924 (S)-piperidine-2-carboxylic acid with an ee value of 97.3% (20% yield) was isolated.