84501-64-4

Basic information

• Product Name: PIPERAZINE-2-CARBOXAMIDE
• Synonyms: (+/-)-PIPERAZINE-2-AMIDE;PIPERAZINE-2-CARBOXAMIDE;2-Piperazinecarboxamide(6CI,9CI);(+/-)-Piperazin-2-amide;2-Carbamoylpiperazine
• CAS NO: 84501-64-4
• Molecular Formula: C₅H₁₁N₃O
• Molecular Weight: 129.16
• EINECS: 282-984-3
• Product Categories: AMIDE;pharmacetical;Pyrans, Piperidines & Piperazines
• Mol File: 84501-64-4.mol
• Article Data: 7

Chemical Properties

• Melting Point: 144-145 °C(Solv: ethanol (64-17-5))
• Boiling Point: 364.2 °C at 760 mmHg
• Flash Point: 174 °C
• Appearance: /
• Density: 1.104 g/cm³
• Vapor Pressure: 1.72E-05mmHg at 25°C
• Refractive Index: 1.48
• Storage Temp.: 2-8°C
• PKA: 16.52±0.20(Predicted)
• CAS DataBase Reference: PIPERAZINE-2-CARBOXAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: PIPERAZINE-2-CARBOXAMIDE(84501-64-4)
• EPA Substance Registry System: PIPERAZINE-2-CARBOXAMIDE(84501-64-4)

Safety Data

• Hazardous Substances Data: 84501-64-4(Hazardous Substances Data)

Usage

Description

PIPERAZINE-2-CARBOXAMIDE, also known as piperazine amide, is a chemical compound characterized by the molecular formula C6H10N4O. It presents as a white crystalline powder that exhibits solubility in water and alcohol. PIPERAZINE-2-CARBOXAMIDE serves as a versatile intermediate in the pharmaceutical industry, playing a crucial role in the synthesis of a range of medications.

Uses

Used in Pharmaceutical Industry:
PIPERAZINE-2-CARBOXAMIDE is used as a key intermediate in the synthesis of various drugs for its ability to contribute to their therapeutic effects. It is particularly utilized in the production of antihistamines, antipsychotics, and antimalarial agents, enhancing their efficacy and performance in treating respective conditions.
Used in Research and Development:
In the realm of scientific research, PIPERAZINE-2-CARBOXAMIDE is employed as a building block in the development of new pharmaceutical compounds. Its versatile properties and reactivity make it an essential component in the creation of innovative medications, pushing the boundaries of medical treatment and care.

InChI:InChI=1/C5H11N3O/c6-5(9)4-3-7-1-2-8-4/h4,7-8H,1-3H2,(H2,6,9)

Upstream product

• 188847-59-8 1,4-dibenzyl-piperazine-2-carboxylic acid amide 
• 98-96-4 pyrazinamide 

Downstream Products

• 31321-68-3 (R)-piperazine-2-carboxylic acid 
• 147650-70-2 (2S)-piperazine-2-carboxylic acid 
• 100828-16-8 4-(3-phosphonopropyl)-2-piperazinecarboxylic acid 
• 112257-24-6 tert-butyl 3-(aminocarbonyl)piperazine-1-carboxylate 
• 83898-63-9 hexahydro-3,3-dimethylimidazo[1,5-a]pyrazin-1(5H)-one 

Relevant articles and documents

Integration of enabling methods for the automated flow preparation of piperazine-2-carboxamide

Here we describe the use of a new open-source software package and a Raspberry Pi computer for the simultaneous control of multiple flow chemistry devices and its application to a machine-assisted, multi-step flow preparation of pyrazine-2-carboxamide - a component of Rifater, used in the treatment of tuberculosis - and its reduced derivative piperazine-2- carboxamide.

Piperazine additions to C60 - A facile approach to fullerene substitution

A range of fullerene monoadducts can be generated via the photochemical reaction of piperazine derivatives with C60. Addend functionality can also be efficiently incorporated by transformation of the hydroxyl-substituted adduct prepared in this fashion. Reaction yields and process simplicity compete with current standard procedures for fullerene mono-functionalisation. The Royal Society of Chemistry 2005.

Method of preventing or limiting reperfusion damage

There is disclosed a process for preparing (l)-(-)-2-aminocarbonyl)-N-(4-amino-2,6-dichlorophenyl)-4-?5,5-bis(4-fluorophenyl)pentyl!-1-piperazineacetamide which comprises the steps of (a) cyclizing (-)-(S,S)-N1,N2 -bis(1-phenylethyl)-1,2-ethanediamine with 2,3-dibromopropanamide in a reaction-inert solvent in the presence of a base, thus yielding an intermediate; (b) resolving the intermediate of into two stereoisomers and recovering thereby ?1(S),2A,4(S)!-1,4-bis(1-phenylethyl)-2-piperazinecarboxamide; (c) hydrogenolyzing ?1(S),2A,4(S)!-1,4-bis(1-phenylethyl)-2-piperazinecarboxamide under a hydrogen atmosphere in an alkanol in the presence of a hydrogenation catalyst to produce (+) -2-piperazinecarboxamide; (d) reductively N-alkylating (+)-2-piperazinecarboxamide with 5,5-bis(4-fluorophenyl)pentaldehyde under a hydrogen atmosphere in an alkanol in the presence of a hydrogenation catalyst to produce a compound of the formula: STR1 (e) N-alkylating the compound of Formula (VII) with an alkylating reagent of the formula: STR2 wherein W represents a reactive leaving group, in a reaction-inert solvent in the presence of a base to form the nitro analog of the desired compound; and (f) reducing the nitro compound in the presence of a reducing agent in a reaction-inert solvent.