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84501-64-4

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84501-64-4 Usage

Description

PIPERAZINE-2-CARBOXAMIDE, also known as piperazine amide, is a chemical compound characterized by the molecular formula C6H10N4O. It presents as a white crystalline powder that exhibits solubility in water and alcohol. PIPERAZINE-2-CARBOXAMIDE serves as a versatile intermediate in the pharmaceutical industry, playing a crucial role in the synthesis of a range of medications.

Uses

Used in Pharmaceutical Industry:
PIPERAZINE-2-CARBOXAMIDE is used as a key intermediate in the synthesis of various drugs for its ability to contribute to their therapeutic effects. It is particularly utilized in the production of antihistamines, antipsychotics, and antimalarial agents, enhancing their efficacy and performance in treating respective conditions.
Used in Research and Development:
In the realm of scientific research, PIPERAZINE-2-CARBOXAMIDE is employed as a building block in the development of new pharmaceutical compounds. Its versatile properties and reactivity make it an essential component in the creation of innovative medications, pushing the boundaries of medical treatment and care.

Check Digit Verification of cas no

The CAS Registry Mumber 84501-64-4 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 8,4,5,0 and 1 respectively; the second part has 2 digits, 6 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 84501-64:
(7*8)+(6*4)+(5*5)+(4*0)+(3*1)+(2*6)+(1*4)=124
124 % 10 = 4
So 84501-64-4 is a valid CAS Registry Number.
InChI:InChI=1/C5H11N3O/c6-5(9)4-3-7-1-2-8-4/h4,7-8H,1-3H2,(H2,6,9)

84501-64-4SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name Piperazine-2-carboxamide

1.2 Other means of identification

Product number -
Other names 2-piperazine acid amide

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:84501-64-4 SDS

84501-64-4Relevant articles and documents

Integration of enabling methods for the automated flow preparation of piperazine-2-carboxamide

Ingham, Richard J.,Battilocchio, Claudio,Hawkins, Joel M.,Ley, Steven V.

, p. 641 - 652 (2014)

Here we describe the use of a new open-source software package and a Raspberry Pi computer for the simultaneous control of multiple flow chemistry devices and its application to a machine-assisted, multi-step flow preparation of pyrazine-2-carboxamide - a component of Rifater, used in the treatment of tuberculosis - and its reduced derivative piperazine-2- carboxamide.

Piperazine additions to C60 - A facile approach to fullerene substitution

Butts, Craig P.,Jazdzyk, Mikael D. S.

, p. 1209 - 1215 (2007/10/03)

A range of fullerene monoadducts can be generated via the photochemical reaction of piperazine derivatives with C60. Addend functionality can also be efficiently incorporated by transformation of the hydroxyl-substituted adduct prepared in this fashion. Reaction yields and process simplicity compete with current standard procedures for fullerene mono-functionalisation. The Royal Society of Chemistry 2005.

Method of preventing or limiting reperfusion damage

-

, (2008/06/13)

There is disclosed a process for preparing (l)-(-)-2-aminocarbonyl)-N-(4-amino-2,6-dichlorophenyl)-4-?5,5-bis(4-fluorophenyl)pentyl!-1-piperazineacetamide which comprises the steps of (a) cyclizing (-)-(S,S)-N1,N2 -bis(1-phenylethyl)-1,2-ethanediamine with 2,3-dibromopropanamide in a reaction-inert solvent in the presence of a base, thus yielding an intermediate; (b) resolving the intermediate of into two stereoisomers and recovering thereby ?1(S),2A,4(S)!-1,4-bis(1-phenylethyl)-2-piperazinecarboxamide; (c) hydrogenolyzing ?1(S),2A,4(S)!-1,4-bis(1-phenylethyl)-2-piperazinecarboxamide under a hydrogen atmosphere in an alkanol in the presence of a hydrogenation catalyst to produce (+) -2-piperazinecarboxamide; (d) reductively N-alkylating (+)-2-piperazinecarboxamide with 5,5-bis(4-fluorophenyl)pentaldehyde under a hydrogen atmosphere in an alkanol in the presence of a hydrogenation catalyst to produce a compound of the formula: STR1 (e) N-alkylating the compound of Formula (VII) with an alkylating reagent of the formula: STR2 wherein W represents a reactive leaving group, in a reaction-inert solvent in the presence of a base to form the nitro analog of the desired compound; and (f) reducing the nitro compound in the presence of a reducing agent in a reaction-inert solvent.

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