84501-64-4Relevant articles and documents
Integration of enabling methods for the automated flow preparation of piperazine-2-carboxamide
Ingham, Richard J.,Battilocchio, Claudio,Hawkins, Joel M.,Ley, Steven V.
, p. 641 - 652 (2014)
Here we describe the use of a new open-source software package and a Raspberry Pi computer for the simultaneous control of multiple flow chemistry devices and its application to a machine-assisted, multi-step flow preparation of pyrazine-2-carboxamide - a component of Rifater, used in the treatment of tuberculosis - and its reduced derivative piperazine-2- carboxamide.
Piperazine additions to C60 - A facile approach to fullerene substitution
Butts, Craig P.,Jazdzyk, Mikael D. S.
, p. 1209 - 1215 (2007/10/03)
A range of fullerene monoadducts can be generated via the photochemical reaction of piperazine derivatives with C60. Addend functionality can also be efficiently incorporated by transformation of the hydroxyl-substituted adduct prepared in this fashion. Reaction yields and process simplicity compete with current standard procedures for fullerene mono-functionalisation. The Royal Society of Chemistry 2005.
Method of preventing or limiting reperfusion damage
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, (2008/06/13)
There is disclosed a process for preparing (l)-(-)-2-aminocarbonyl)-N-(4-amino-2,6-dichlorophenyl)-4-?5,5-bis(4-fluorophenyl)pentyl!-1-piperazineacetamide which comprises the steps of (a) cyclizing (-)-(S,S)-N1,N2 -bis(1-phenylethyl)-1,2-ethanediamine with 2,3-dibromopropanamide in a reaction-inert solvent in the presence of a base, thus yielding an intermediate; (b) resolving the intermediate of into two stereoisomers and recovering thereby ?1(S),2A,4(S)!-1,4-bis(1-phenylethyl)-2-piperazinecarboxamide; (c) hydrogenolyzing ?1(S),2A,4(S)!-1,4-bis(1-phenylethyl)-2-piperazinecarboxamide under a hydrogen atmosphere in an alkanol in the presence of a hydrogenation catalyst to produce (+) -2-piperazinecarboxamide; (d) reductively N-alkylating (+)-2-piperazinecarboxamide with 5,5-bis(4-fluorophenyl)pentaldehyde under a hydrogen atmosphere in an alkanol in the presence of a hydrogenation catalyst to produce a compound of the formula: STR1 (e) N-alkylating the compound of Formula (VII) with an alkylating reagent of the formula: STR2 wherein W represents a reactive leaving group, in a reaction-inert solvent in the presence of a base to form the nitro analog of the desired compound; and (f) reducing the nitro compound in the presence of a reducing agent in a reaction-inert solvent.