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Usage

Uses

Used in Pharmaceutical Industry:
2,2-Diphenyl-N-[4-(thiazol-2-ylsulfamoyl)-phenyl]-acetamide is used as a potential therapeutic agent for targeting specific biological pathways. Its unique structure allows it to interact with various proteins and enzymes, making it a candidate for the development of new drugs to treat a range of diseases.
Used in Chemical Research:
In the field of chemical research, 2,2-Diphenyl-N-[4-(thiazol-2-ylsulfamoyl)-phenyl]-acetamide serves as a valuable compound for studying the properties and reactivity of similar organic molecules. Its synthesis and modification can provide insights into the development of new chemical processes and the creation of novel compounds with specific applications.
Used in Voltage-gated Sodium (Nav) Channel Inhibition:
2,2-Diphenyl-N-[4-(thiazol-2-ylsulfamoyl)-phenyl]-acetamide is used as a Nav channel inhibitor, specifically targeting Nav1.1 and Nav1.3 channels over other Nav channels. This selective inhibition can be beneficial in the treatment of conditions related to the abnormal functioning of these channels, such as certain types of pain, epilepsy, and other neurological disorders. 2,2-Diphenyl-N-[4-(thiazol-2-ylsulfamoyl)-phenyl]-acetamide induces a hyperpolarizing shift in the voltage dependence of inactivation of Nav1.3 channels, providing a potential therapeutic effect at concentrations as low as 1 μM.

References

McCormack et al. (2013), Voltage sensor interaction site for selective small molecule inhibitors of voltage-gated sodium channels; Proc. Natl. Acad. Sci. USA 110 E2724 Ostenn et al. (2017), Pharmacology of the Nav1.1 domain IV voltage sensor reveals coupling between inactivation gating processes; Proc. Natl. Acad. Sci. USA 114 6836