313339-35-4

Basic information

• Product Name: 4,6-DICHLORO-2-(METHYLTHIO)PYRIMIDINE-5-CARBOXYLIC ACID
• Synonyms: 4,6-DICHLORO-2-(METHYLTHIO)PYRIMIDINE-5-CARBOXYLIC ACID;RARECHEM AL BO 1988;4,6-dichloro-2-(Methylsulfanyl)pyriMidine-5-carboxylic acid;4,6-dichloro-2-(Methylthio)-5-pyriMidine carboxylic acid
• CAS NO: 313339-35-4
• Molecular Formula: C₆H₄Cl₂N₂O₂S
• Molecular Weight: 239.08
• Product Categories: Building Blocks;C6 to C8;Chemical Synthesis;Halogenated Heterocycles;Heterocyclic Building Blocks;Pyrimidines;Heterocycle-Pyrimidine series
• Mol File: 313339-35-4.mol
• Article Data: 10

Chemical Properties

• Melting Point: 159-163℃
• Boiling Point: 384.523ºC at 760 mmHg
• Flash Point: 186.353ºC
• Appearance: /
• Density: 1.716g/cm3
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.652
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: 0.08±0.32(Predicted)
• CAS DataBase Reference: 4,6-DICHLORO-2-(METHYLTHIO)PYRIMIDINE-5-CARBOXYLIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 4,6-DICHLORO-2-(METHYLTHIO)PYRIMIDINE-5-CARBOXYLIC ACID(313339-35-4)
• EPA Substance Registry System: 4,6-DICHLORO-2-(METHYLTHIO)PYRIMIDINE-5-CARBOXYLIC ACID(313339-35-4)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26
• WGK Germany: 3
• Hazardous Substances Data: 313339-35-4(Hazardous Substances Data)

Usage

General Description

4,6-Dichloro-2-(methylthio)pyrimidine-5-carboxylic acid is a chemical compound that belongs to the class of pyrimidine derivatives. It is a white to off-white solid that is slightly soluble in water and soluble in organic solvents. 4,6-DICHLORO-2-(METHYLTHIO)PYRIMIDINE-5-CARBOXYLIC ACID is commonly used as an intermediate in the synthesis of pharmaceuticals and agrochemicals. It has been studied for its potential antimicrobial and antifungal properties. Additionally, its unique structural properties make it a valuable building block in the field of organic chemistry for the development of various biologically active compounds. Overall, 4,6-dichloro-2-(methylthio)pyrimidine-5-carboxylic acid has several important applications in the pharmaceutical and agricultural industries, making it a valuable and versatile chemical compound.

InChI:InChI=1/C6H4Cl2N2O2S/c1-13-6-9-3(7)2(5(11)12)4(8)10-6/h1H3,(H,11,12)

Upstream product

• 6299-25-8 4,6-Dichloro-2-(methylthio)pyrimidine 
• 124-38-9 carbon dioxide 
• 1979-98-2 4,6-dihydroxy-2-methylmercaptopyrimidine 
• 33097-11-9 4,6-dichloro-2-methylsulfanylpyrimidine-5-carboxyaldehyde 

Downstream Products

• 959070-42-9 4,6-dichloro-2-(methylthio)pyrimidine-5-carboxylic acid ethyl ester 
• 1269119-30-3 benzyl 4-chloro-5-hydroxy-7-methyl-2-(methylsulfanyl)-7H-pyrrolo[2,3-d]pyrimidine-6-carboxylate 
• 1269119-34-7 benzyl 4-chloro-7-methyl-5-(1-methylethoxy)-2-(methylsulfanyl)-7H-pyrrolo[2,3-d]pyrimidine-6-carboxylate 
• 1269119-37-0 benzyl 7-methyl-5-(1-methylethoxy)-2-(methylsulfanyl)-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidine-6-carboxylate 
• 1269119-32-5 C₁₈H₂₀ClN₃O₄S 
• 1448988-02-0 [4-(6-ethyl-8,8-dimethyl-2-methylsulfanyl-5-oxo-5,6,7,8-tetrahydro-9-oxa-1,3,6-triazabenzocyclohepten-4-yl)-3-fluorophenyl]carbamic acid tert-butyl ester 
• 1448985-17-8 1-{4-[6-ethyl-8,8-dimethyl-2-((S)-3-methylmorpholin-4-yl)-5-oxo-5,6,7,8-tetrahydro-9-oxa-1,3,6-triazabenzocyclohepten-4-yl]-3-fluorophenyl}-3-methylurea 
• 1448988-01-9 1-ethyl-3-[4-(6-ethyl-2-methanesulfonyl-8,8-dimethyl-5-oxo-6,7,8,9-tetrahydro-5H-10-oxa-1,3,6-triazabenzocycloocten-4-yl)phenyl]urea 

Relevant articles and documents

BICYCLIC CARBOXAMIDE INHIBITORS OF KINASES

The present invention relates to compounds of formula (I) or pharmaceutical acceptable salts, wherein X1, X2, X3, X4, R1, R2, R3, A, B, Z, n, and m are defined in the description. The present invention relates also to compositions containing said compounds which are useful for inhibiting kinases such as ALK and methods of treating diseases such as cancer.

PYRIMIDODIAZEPINONE DERIVATIVE

The invention provides a pyrimidodiazepinone derivative represented by the general formula (I) [wherein n represents 1 or 2, Z represents a hydrogen atom or the like, R1 and R2 may be the same or different, and each represents a hydrogen atom or the like, A represents a bond, (CH2)m (wherein m represents an integer of 1 to 4), optionally substituted phenylene, optionally substituted pyridinediyl, or C=O, R3 represents a hydrogen atom, optionally substituted lower alkyl, or the like, and R4 represents a hydrogen atom or the like], or a pharmaceutically acceptable salt thereof or the like.

ALICYCLIC HETEROCYCLIC COMPOUND

An alicyclic heterocyclic compound represented by the following formula or a pharmaceutically acceptable salt thereof: wherein ring A is a heterocyclic ring, ring B is a carbocyclic ring, a heterocyclic ring etc., P1 and P2 are CH or N, q and r are 0 to 2, X is -NH-, -O-, -CH2-, etc., Y is -CH2-, -CO-, -SO2-, etc., Z is -CO-, -SO2-, etc., and R3 is carbocyclic group, heterocyclic group, hydroxyl, alkoxy or amino, is useful as a controlling agent of the function of CCR4 useful for the prevention or treatment for bronchial asthma, atopic dermatitis, etc.