313339-92-3

Usage

Uses

Used in Pharmaceutical Synthesis:
3,5-Dichloropyrazine-2-carbonitrile is used as a key intermediate in the synthesis of various pharmaceuticals. Its unique structure allows for the development of new drugs with potential therapeutic benefits.
Used in Agrochemical Production:
In the agrochemical industry, 3,5-Dichloropyrazine-2-carbonitrile is utilized as an intermediate for the production of insecticides, herbicides, and fungicides. Its reactivity contributes to the creation of effective compounds designed to protect crops and enhance agricultural productivity.
Used in Organic Compound Synthesis:
3,5-Dichloropyrazine-2-carbonitrile is employed as an intermediate in the synthesis of other organic compounds, broadening its applications across various chemical industries. Its versatility in chemical reactions makes it a sought-after component in the development of novel organic molecules for different uses.
Given the compound's high reactivity and toxicity, it is crucial to implement proper safety measures during its production, handling, and use to minimize risks to human health and the environment.

InChI:InChI=1/C5HCl2N3/c6-4-2-9-3(1-8)5(7)10-4/h2H

Upstream product

• 312736-50-8 3,5-dichloropyrazine-2-carboxamide 
• 1207852-78-5 (E)-1-(3,5-dichloropyrazin-2-yl)-N-hydroxymethanimine 

Downstream Products

• 1426214-90-5 N-[4-(3-amino-1H-pyrazolo[3,4-b]pyrazin-6-yl) phenyl]-2-chloro-5-methoxy-benzenesulfonamide 
• 1426215-67-9 C₁₁H₁₀N₆ 
• 1426214-82-5 [4-(3-methyl-1H-pyrazolo[3,4-b]pyrazin-6-yl)-phenyl]-carbamic acid tert-butyl ester 
• 1426214-83-6 2-cyano-5-methyl-N-[4-(3-methyl-1H-pyrazolo[3,4-b]pyrazin-6-yl)phenyl]benzenesulfonamide 
• 1426214-81-4 [4-(5-acetyl-6-chloro-pyrazin-2-yl)-phenyl]-carbamic acid tert-butyl ester 
• 1426214-88-1 [4-(6-chloro-5-cyanopyrazine-2-yl)phenyl]aminoformic acid tert-butyl ester 

Relevant academic research and scientific papers

Synthesis method of 3,5-dichloro-6-ethylpyrazineformamide

The invention discloses a synthetic method of 3,5-dichloro-6-ethylpyrazine formamide, and relates to the technical field of intermediate for synthesizing gilteritinib. The method is technically characterized by comprising the following steps: heating 2,6-dichloropyrazine and formamide to 70-130 DEG C, and carrying out free radical oxidation reaction under the action of persulfate to obtain 3,5-dichloropyrazine formamide; carrying out heating reflux on 3,5-dichloropyrazine formamide for 3-6 h under the action of a dehydrating agent, and synthesizing 3,5-dichloropyrazine formonitrile through dehydration; carrying out a Grignard reactionon the 3,5-dichloropyrazine formonitrile in an organic solvent A under the action of a methylation reagent to prepare 3,5-dichloro-2-acetylpyrazine; under theaction of an acidic catalyst and a silicon-hydrogen reducing agent, reducing the 3,5-dichloro-2-acetyl pyrazine in an organic solvent B to obtain 3,5-dichloro-2-ethyl pyrazine; and heating the 3,5-dichloro-2-ethyl pyrazine and formamide to 50-120 DEG C, and carrying out free radical oxidation reaction under the action of persulfate to obtain the 3,5-dichloro-6-ethylpyrazine formamide. According to the invention, the operation method is simple, the reaction conditions of the synthesis process are mild, the cost is reduced, and meanwhile high economic benefits can be brought.

CHEMOKINE RECEPTOR MODULATORS AND USES THEREOF

Disclosed herein, inter alia, are compounds and methods of use thereof for the modulation of CCR4 activity.

CHEMOKINE RECEPTOR MODULATORS AND USES THEREOF

Disclosed herein, inter alia, are compounds and methods of use thereof for the modulation of chemokine receptor activity.

NOVEL IMIDAZOTRIAZINONE OR IMIDAZOPYRAZINONE DERIVATIVES, AND USE THEREOF

The present invention relates to novel a imidazotriazinone or imidazopyrazinone derivative, a tautomer thereof, a stereoisomer thereof and their mixture, or a pharmaceutically acceptable salt thereof; and a pharmaceutical composition for preventing or treating a tankyrase-related disease, which contains the same as an active ingredient.

Novel imidazotriazinone or imidazopyrazinone derivatives, and use thereof

The present invention relates to a novel imidazotriazinone or imidazopyrazinone derivatives, a tautomer thereof, a stereomer and a mixture thereof, or a pharmaceutically acceptable salt thereof; and a pharmaceutical composition for preventing or treating tankyrase-related diseases comprising the same as active components.COPYRIGHT KIPO 2016

Studies on the regioselective nucleophilic aromatic substitution (S NAr) reaction of 2-substituted 3,5-dichloropyrazines

Differences in regioselectivity were observed during the SNAr reaction of amines with unsymmetrical 3,5-dichloropyrazines. This study revealed that when the 2-position of the pyrazine was occupied with an electron-withdrawing group (EWG), nucle

6 SUBSTITUTED 2-HETEROCYCLYLAMINO PYRAZINE COMPOUNDS AS CHK-1 INHIBITORS

The present invention is directed to compounds of formula (I), and pharmaceutically acceptable salts thereof, their synthesis, and their use as CHK-1 inhibitors.