313340-78-2Relevant academic research and scientific papers
Synthesis of new covalently bound κ-carrageenan-AZT conjugates with improved anti-HIV activities
Vlieghe, Patrick,Clerc, Thierry,Pannecouque, Christophe,Witvrouw, Myriam,De Clercq, Erik,Salles, Jean-Pierre,Kraus, Jean-Louis
, p. 1275 - 1283 (2002)
This paper describes the first covalent synthesis of κ-carrageenan-3′-azido-3′-deoxythymidine (AZT) conjugates. A succinate diester spacer was used to covalently couple AZT onto κ-carrageenan, resulting in a tripartite prodrug. Two methods (UV and radioac
