313343-90-7Relevant academic research and scientific papers
Synthesis of 1,5-diphenylpent-3-en-1-yne derivatives utilizing an aqueous B-alkyl Suzuki cross coupling reaction
Chuang, Da-Wei,El-Shazly, Mohamed,Chen, Chin-Chau,Chung, Yu-Ming,D. Barve, Balaji,Wu, Ming-Jung,Chang, Fang-Rong,Wu, Yang-Chang
supporting information, p. 5162 - 5166 (2013/09/02)
1,5-Diphenylpent-3-en-1-yne derivatives were isolated in minor quantities from terrestrial plants and exhibited strong anti-inflammatory activity. A cross coupling reaction between B-benzyl-9-BBN and chloroenynes under mild condition was developed resulti
A strictly "pair"-selective synthesis of conjugated diynes via Pd-catalyzed cross coupling of 1,3-diynylzincs: A superior alternative to the Cadiot-Chodkiewicz reaction
Negishi, Ei-Ichi,Hata, Mitsuhiro,Xu, Caiding
, p. 3687 - 3689 (2007/10/03)
(matrix presented) A strictly "pair"-selective synthesis of conjugated diynes via Pd-catalyzed cross coupling of 1,3-diynylzincs is described. This method, like the Cadiot-Chodkiewicz reaction, requires three steps for the synthesis of R1C≡CC≡CR2 from R1C≡CH, R2X, and HC≡CH. However, the high "pair"-selectivity permitting high-yield production of the desired conjugated diynes without separation of symmetrical diynes promises to make the present protocol superior to the Cadiot-Chodkiewicz reaction in many cases.
