313350-36-6

Basic information

• Product Name: 6-MORPHOLINONICOTINOYL CHLORIDE
• Synonyms: 6-Morpholinopyridine-3-carbonyl chloride;6-MORPHOLINOPYRIDINE-3-CARBONYL CHLORIDE HCL;6-(Morpholin-4-yl)pyridine-3-carbonyl chloride;BUTTPARK 98\12-33;6-MORPHOLINONICOTINOYL CHLORIDE;6-(4-Morpholino)nicotinoyl chloride;6-(Morpholin-4-yl)nicotinoyl chloride;6-(Morpholin-4-yl)pyridine-3-carbonyl chloride, 3-(Chlorocarbonyl)-6-(morpholin-4-yl)pyridine, 4-[5-(Chlorocarbonyl)pyridin-2-yl]morpholine
• CAS NO: 313350-36-6
• Molecular Formula: C₁₀H₁₁ClN₂O₂
• Molecular Weight: 226.66
• Mol File: 313350-36-6.mol
• Article Data: 2

Chemical Properties

• Melting Point: 122-124°C
• Boiling Point: 400.9 °C at 760 mmHg
• Flash Point: 196.3 °C
• Appearance: /
• Density: 1.314 g/cm³
• Vapor Pressure: 1.23E-06mmHg at 25°C
• Refractive Index: 1.568
• PKA: 2.66±0.10(Predicted)
• CAS DataBase Reference: 6-MORPHOLINONICOTINOYL CHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 6-MORPHOLINONICOTINOYL CHLORIDE(313350-36-6)
• EPA Substance Registry System: 6-MORPHOLINONICOTINOYL CHLORIDE(313350-36-6)

Safety Data

• Hazard Codes: C
• Statements: 34
• Safety Statements: 26-36/37/39-45
• RIDADR: 3261
• Hazardous Substances Data: 313350-36-6(Hazardous Substances Data)

Usage

Description

6-Morpholinonicotinoyl chloride, commonly referred to as Mochlo, is a chlorinated derivative of the 6-morpholinonicotinoyl group, featuring both morpholine and nicotinoyl moieties. This chemical compound is a key intermediate in the pharmaceutical industry, utilized for the synthesis of a diverse array of drugs and drug precursors. Its versatility as a building block extends to the creation of antiviral and anticancer agents, as well as its application in the synthesis of agrochemicals. Given its reactivity, 6-Morpholinonicotinoyl chloride requires careful handling by trained professionals within a controlled laboratory environment.

Uses

Used in Pharmaceutical Industry:
6-Morpholinonicotinoyl chloride is used as a chemical intermediate for the synthesis of various pharmaceuticals, including antiviral and anticancer agents, due to its ability to facilitate the creation of a wide range of drug molecules.
Used in Agrochemical Synthesis:
In the agrochemical industry, 6-Morpholinonicotinoyl chloride is used as a precursor in the production of various agrochemicals, contributing to the development of compounds that can protect crops and enhance agricultural productivity.
Used in Research and Development:
6-Morpholinonicotinoyl chloride is utilized as a research tool in the development of new drug candidates and for studying the chemical properties and reactions of related compounds in a laboratory setting.

InChI:InChI=1/C10H11ClN2O2/c11-10(14)8-1-2-9(12-7-8)13-3-5-15-6-4-13/h1-2,7H,3-6H2

Upstream product

• 167640-97-3 isopropyl 6-morpholinonicotinate 
• 313350-11-7 isopropyl 6-chloronicotinate 
• 5326-23-8 6-Chloro-3-pyridinecarboxylic acid 
• 79-37-8 oxalyl dichloride 
• 120800-52-4 6-morpholin-4-ylpyridine-3-carboxylic acid 
• 68-12-2 N,N-dimethyl-formamide 

Downstream Products

• 1402048-21-8 [4-(3,5-di-tert-butyl-4-hydroxy-phenylsulfanyl)-4-(3,5-di-tert-butyl-4-methoxy-phenylsulfanyl)-piperidin-1-yl]-(6-morpholin-4-yl-pyridin-3-yl)-methanone 
• 955967-49-4 N-{(R)-1-[9-((1R,2S,3R,4S)-2,3-dihydroxy-4-propionylaminocyclopentyl)-6-(2,2-diphenylethylamino)-9H-purin-2-yl]pyrrolidin-3-yl}-6-morpholin-4-yl-nicotinamide trifluoroacetate 
• 861905-54-6 (4-bromo-2-fluorophenyl)[6-(4-morpholinyl)-3-pyridinyl]methanone 

Relevant articles and documents

Amide substituted imidazoquinolines

Imidazoquinoline and tetrahydroimidazoquinoline compounds that contain amide functionality at the 1-position are useful as immune response modifiers. The compounds and compositions of the invention can induce the biosynthesis of various cytokines and are useful in the treatment of a variety of conditions including viral diseases and neoplastic diseases.