313398-26-4Relevant academic research and scientific papers
An environmentally benign, green, and efficient ionic liquid catalyzed synthesis of Quinoline derivatives via Knoevenagel condensation
Tasqeeruddin, Syed,Asiri, Yahya I.
, p. 132 - 139 (2020)
The present investigation is in the interest of one-pot, environmentally friendly and efficient protocol for the synthesis of quinoline derivatives from 2-aminoarylketones and active methylene compounds in the presence of L-proline and ionic liquid 1,3-di
An efficient and green microwave-assisted synthesis of quinoline derivatives via knoevengal condensation
Tasqeeruddin, Syed,Asiri, Yahya,Alsherhri, Jaber Abdullah
supporting information, p. 157 - 163 (2020/02/04)
We have developed an efficient and green synthesis of quinoline derivatives using L-proline under Knoevenagel condensation. L-proline was found to be an efficient catalyst for the Knoevenagel condensation of substituted 2-aminoaryl ketones 1 with the acti
Environmentally Friendly Nafion-Mediated Friedl?nder Quinoline Synthesis under Microwave Irradiation: Application to One-Pot Synthesis of Substituted Quinolinyl Chalcones
Chan, Chieh-Kai,Lai, Chien-Yu,Wang, Cheng-Chung
, p. 1779 - 1794 (2020/06/08)
An efficient and eco-friendly synthetic route for Friedl?nder quinoline synthesis of polysubstituted quinolines is described. This green chemical method starts from various 2-aminobenzophenones and mono- or dicarbonyl synthons and uses reusable Nafion NR50 material as a solid catalyst in ethanol under microwave irradiation. The protocol has a high generality of functional groups and provides the desired quinolines in good to excellent yields. Some structures were confirmed by single-crystal X-ray diffraction analysis.
A hydrazine functionalized UiO-66(Hf) metal-organic framework for the synthesis of quinolines via Friedl?nder condensation
Das, Aniruddha,Anbu, Nagaraj,Varalakshmi, Perumal,Dhakshinamoorthy, Amarajothi,Biswas, Shyam
, p. 10982 - 10988 (2020/08/21)
A hydrazine functionalized Hf-UiO-66 metal-organic framework (MOF) (called 1) was prepared using the traditional solvothermal method and it was characterized completely. The material showed high chemical stability in various solvent systems. The activated material (called 1′) was successfully used as a solid heterogeneous catalyst for the synthesis of quinolone scaffolds in a modified Friedl?nder synthesis. The catalyst was able to produce 95% yield of the product 3-acetyl-2,4-dimethylquinoline via Friedl?nder condensation of 2-aminoacetophenone and acetylacetone as starting materials at 100 °C. It also exhibited a broad substrate scope in this catalytic reaction. Various control experiments were carried out with respect to the activity of the presented catalyst which clearly indicated its active role. The stability and recyclability of the catalyst were also examined. A series of control experiments for this catalysis have shown that the Lewis acidic metal nodes and Br?nsted acidic -NHNH2 functional groups of linker play active roles in the catalysis.
Highly efficient Br?nsted acid and Lewis acid catalysis systems for the Friedl?nder Quinoline synthesis
Zhou, Xiao-Yu,Chen, Xia,Wang, Liang-Guang
supporting information, p. 830 - 837 (2018/03/12)
The efficient and green Br?nsted acid or Lewis acid catalysis systems for the Friedl?nder synthesis of 2,3,4-trisubstituted quinolines from the condensation of 2-aminoarylketones and β-ketoesters/ketones had been developed. The results confirmed that 4-to
