313471-11-3Relevant academic research and scientific papers
Modified coumarins. 5. Amino-acid derivatives of 3-hydroxy-7,8,9,10-tetrahydrobenzo[c]chromen-6-one
Garazd,Garazd,Shilin,Khilya
, p. 416 - 423 (2002)
Peptide-chemistry methods (symmetric anhydrides and activated esters) and the Mannich reaction were used to prepare various conjugates of amino acids with 7,8,9,10-tetrahydrobenzo[c]chromen-6-one in which the amino acids are bound to the coumarin by the C- or N-terminus.
Design, synthesis, and biological evaluation of new urolithin amides as multitarget agents against Alzheimer's disease
Shukur, Karar T.,Ercetin, Tugba,Luise, Chiara,Sippl, Wolfgang,Sirkecioglu, Okan,Ulgen, Mert,Coskun, Goknil P.,Yarim, Mine,Gazi, Mustafa,Gulcan, Hayrettin O.
, (2021/02/01)
A series of urolithin amide (i.e., URO-4–URO-10 and THU-4–THU-10) derivatives was designed and synthesized, and their chemical structures were confirmed with spectroscopic techniques and elemental analysis. The title compounds and synthesis intermediates
Synthesis of Fluorescent Probes Targeting Tumor-Suppressor Protein FHIT and Identification of Apoptosis-Inducing FHIT Inhibitors
Kawaguchi, Mitsuyasu,Sekimoto, Eriko,Ohta, Yuhei,Ieda, Naoya,Murakami, Takashi,Nakagawa, Hidehiko
, p. 9567 - 9576 (2021/07/19)
For the early diagnosis of cancer, leading to a better chance of full recovery, marker genes whose expression is already altered in precancerous lesions are desirable, and the tumor-suppressor gene FHIT is one candidate. The gene product, FHIT protein, has a unique dinucleoside triphosphate hydrolase (AP3Aase) activity, and in this study, we designed and synthesized a series of FHIT fluorescent probes utilizing this activity. We optimized the probe structure for high and specific reactivity with FHIT and applied the optimized probe in a screening assay for FHIT inhibitors. Screening of a compound library with this assay identified several hits. Structural development of a hit compound afforded potent FHIT inhibitors. These inhibitors induce apoptosis in FHIT-expressing cancers via caspase activation. Our results support the idea that FHIT binders, no matter whether inhibitors or agonists of AP3Aase activity, might be promising anticancer agents.
Modified coumarins. 22. Synthesis of N-coumarinyloxyacetyl derivatives of cytisine
Dubovik,Garazd,Vinogradova,Khilya
, p. 133 - 137 (2008/02/01)
N-Acetyl derivatives of cytisine modified by coumarins were synthesized. 2006 Springer Science+Business Media, Inc.
