313496-54-7Relevant academic research and scientific papers
Structure-activity and crystallographic analysis of benzophenone derivatives-the potential anticancer agents.
Hsieh, Hsing-Pang,Liou, Jing-Ping,Lin, Ying-Ting,Mahindroo, Neeraj,Chang, Jang-Yang,Yang, Yung-Ning,Chern, Shuenn-Shing,Tan, Uan-Kang,Chang, Chun-Wei,Chen, Tung-Wei,Lin, Chi-Hung,Chang, Ying-Ying,Wang, Chiung-Chiu
, p. 101 - 105 (2007/10/03)
Compounds 1-5, structurally related to combretastatin A-4 showed excellent cytotoxic activities against a panel of human cancer cell lines including multi-drug resistant cell lines. The X-ray three-dimensional structural analysis shows that proton donor in B ring may be required for cytotoxic activity, with intermolecular hydrogen bonding playing an important role.
