313510-77-9

Basic information

• Product Name: 4-bromo-2-chloro-1-trifluoromethanesulfonyloxybenzene
• Synonyms: 4-bromo-2-chloro-1-trifluoromethanesulfonyloxybenzene
• CAS NO: 313510-77-9
• Molecular Weight: 339.517
• Mol File: 313510-77-9.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 4-bromo-2-chloro-1-trifluoromethanesulfonyloxybenzene(CAS DataBase Reference)
• NIST Chemistry Reference: 4-bromo-2-chloro-1-trifluoromethanesulfonyloxybenzene(313510-77-9)
• EPA Substance Registry System: 4-bromo-2-chloro-1-trifluoromethanesulfonyloxybenzene(313510-77-9)

Safety Data

• Hazardous Substances Data: 313510-77-9(Hazardous Substances Data)

Upstream product

• 358-23-6 trifluoromethylsulfonic anhydride 
• 3964-56-5 4-bromo-2-chlorophenol 

Downstream Products

• 1043912-16-8 4-deutero-4-bromo-2-chloro-1-trifluoromethanesulfonyloxybenzene 
• 318276-22-1 4-[3-(1-azepanyl)prop-1-ynyl]-2-chlorophenyl trifluoromethanesulphonate 

Relevant articles and documents

Modular Functionalization of Arenes in a Triply Selective Sequence: Rapid C(sp2) and C(sp3) Coupling of C?Br, C?OTf, and C?Cl Bonds Enabled by a Single Palladium(I) Dimer

Full control over multiple competing coupling sites would enable straightforward access to densely functionalized compound libraries. Historically, the site selection in Pd0-catalyzed functionalizations of poly(pseudo)halogenated arenes has been unpredictable, being dependent on the employed catalyst, the reaction conditions, and the substrate itself. Building on our previous report of C?Br-selective functionalization in the presence of C?OTf and C?Cl bonds, we herein complete the sequence and demonstrate the first general arylations and alkylations of C?OTf bonds (in I dimer. This allowed the realization of the first general and triply selective sequential C?C coupling (in 2D and 3D space) of C?Br followed by C?OTf and then C?Cl bonds.

Decoupling deprotonation from metalation: Thia-fries rearrangement

(Chemical Equation Presented) Label-enabled: Studies with 2H-, 18O-, and 34S-labeled aryl triflates show that lithium diisopropylamide-mediated thia-Fries rearrangement proceeds through an irreversible ortho deprotonation (see scheme; DIPA = diisopropylamine, LDA = lithium diisopropylamide). In contrast, ortho metalation results exclusively in the generation of a benzyne.