4-bromo-2-chloro-1-trifluoromethanesulfonyloxybenzene

Base Information

• Chemical Name: 4-bromo-2-chloro-1-trifluoromethanesulfonyloxybenzene
• CAS No.: 313510-77-9
• Molecular Formula: C₇H₃BrClF₃O₃S
• Molecular Weight: 339.517
• Mol file: 313510-77-9.mol

Synonyms:4-bromo-2-chloro-1-trifluoromethanesulfonyloxybenzene

Chemical Property of 4-bromo-2-chloro-1-trifluoromethanesulfonyloxybenzene

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-bromo-2-chloro-1-trifluoromethanesulfonyloxybenzene

There total 1 articles about 4-bromo-2-chloro-1-trifluoromethanesulfonyloxybenzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

trifluoromethylsulfonic anhydride (358-23-6) + 4-bromo-2-chlorophenol (3964-56-5) → 4-bromo-2-chloro-1-trifluoromethanesulfonyloxybenzene (313510-77-9)

Guidance literature:

4-bromo-2-chlorophenol; With triethylamine; In dichloromethane; at 20 ℃; for 0.0833333h; Inert atmosphere;

trifluoromethylsulfonic anhydride; In dichloromethane; at -78 - 20 ℃; for 12h; Inert atmosphere;

DOI:10.1002/anie.201808386

Reference yield: 90.0%

4-bromo-2-chloro-1-trifluoromethanesulfonyloxybenzene (313510-77-9) + ethanethiol (75-08-1) → 2-chloro-4-(ethylthio)phenyl trifluoromethanesulfonate

Guidance literature:

ethanethiol; With sodium hydride; In tetrahydrofuran; at 20 ℃; for 1h; Inert atmosphere;

4-bromo-2-chloro-1-trifluoromethanesulfonyloxybenzene; With di-μ-iodobis(tri-t-butylphosphino)dipalladium(l); In tetrahydrofuran; toluene; at 40 ℃; for 12h; chemoselective reaction; Inert atmosphere;

DOI:10.1002/anie.201806036

Reference yield: 86.0%

4-bromo-2-chloro-1-trifluoromethanesulfonyloxybenzene (313510-77-9) + 4-dibenzofurylboronic acid (100124-06-9) + 2-Methylphenylboronic acid (16419-60-6) → C26H17F3O4S

Guidance literature:

4-bromo-2-chloro-1-trifluoromethanesulfonyloxybenzene; 2-Methylphenylboronic acid; With potassium fluoride; palladium diacetate; 2-cyclohexyl-3-(diisopropylphosphino)-1-methyl-1H-indole; In tetrahydrofuran; toluene; at 110 ℃; for 2h; Schlenk technique; Inert atmosphere;

4-dibenzofurylboronic acid; In tetrahydrofuran; toluene; at 110 ℃; for 2h; chemoselective reaction;

upstream raw materials:

trifluoromethylsulfonic anhydride

4-bromo-2-chlorophenol

Downstream raw materials:

4-[3-(1-azepanyl)prop-1-ynyl]-2-chlorophenyl trifluoromethanesulphonate

4-deutero-4-bromo-2-chloro-1-trifluoromethanesulfonyloxybenzene

Refernces

• 1、 Kalvet, Indrek,Magnin, Guillaume,Schoenebeck, Franziska. "Rapid Room-Temperature, Chemoselective Csp2?Csp2Coupling of Poly(pseudo)halogenated Arenes Enabled by Palladium(I) Catalysis in Air". supporting information. p. 1581 - 1585. Retrieved 2017/02/05.