31356-94-2 Usage
Uses
Used in Pharmaceutical Industry:
8-BR-CGMP is used as a research tool for studying the role of cGMP and PKG in various physiological processes and diseases. Its increased potency compared to cGMP makes it a valuable compound for investigating the mechanisms of PKG activation and its downstream effects.
Used in Smooth Muscle Relaxation:
8-BR-CGMP is used as a smooth muscle relaxant for studying the relaxation of tracheal and vascular smooth muscle tissues in vitro. This application helps researchers understand the underlying mechanisms of smooth muscle relaxation and the potential therapeutic applications of 8-BR-CGMP in treating conditions related to smooth muscle dysfunction.
Used in Drug Development:
8-BR-CGMP can be used as a lead compound in the development of new drugs targeting PKG and related pathways. Its enhanced potency and selectivity for PKG1alpha make it a promising candidate for the development of therapeutic agents for various diseases, including those involving smooth muscle dysfunction and other cGMP-related pathologies.
Check Digit Verification of cas no
The CAS Registry Mumber 31356-94-2 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 3,1,3,5 and 6 respectively; the second part has 2 digits, 9 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 31356-94:
(7*3)+(6*1)+(5*3)+(4*5)+(3*6)+(2*9)+(1*4)=102
102 % 10 = 2
So 31356-94-2 is a valid CAS Registry Number.
31356-94-2Relevant academic research and scientific papers
NITROGUANOSINE-3 ,5 -CYCLIC MONOPHOSPHATE AND PROTEIN KINASE G ACTIVATOR
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Page/Page column 5-6, (2008/06/13)
An object of the present invention is to provide a novel compound that is an agonist of guanosine-3',5'-cyclic monophosphate and has an effect of activating protein kinase G. The present invention provides 8-guanosine-3',5'-cyclic monophosphate compound which is represented by the following formula, and a pharmaceutical composition, especially a protein kinase G activating agent, which contains the 8-guanosine-3',5'-cyclic monophosphate compound as an active ingredient.
Coumarinylmethyl esters for ultrafast release of high concentrations of cyclic nucleotides upon one- and two-photon photolysis
Hagen, Volker,Dekowski, Brigitte,Nache, Vasilica,Schmidt, Reinhard,Geissler, Daniel,Lorenz, Dorothea,Eichhorst, Jenny,Keller, Sandra,Kaneko, Hiroshi,Benndorf, Klaus,Wiesner, Burkhard
, p. 7887 - 7891 (2007/10/03)
(Chemical Equation Presented) Shedding light: Efficient activation of cyclic nucleoside monophosphates (cNMPs) can be achieved upon one- and two-photon flash photolysis of novel photolabile coumarinylmethyl esters of cAMP and cGMP (A = adenosine, G = guanosine) as well as their 8-bromosubstituted derivatives. The phototriggers show high solubility in water and permit space- and time-resolved investigations of the molecular mechanisms of cyclic nucleotide dependent processes.
