313673-23-3

Basic information

• Product Name: (4-methoxy-3-nitrobenzyl)(triphenyl)phosphonium bromide
• Synonyms: (4-Methoxy-3-nitrobenzyl)(triphenyl)phosphonium bromide
• CAS NO: 313673-23-3
• Molecular Formula: C₂₆H₂₃BrNO₃P
• Molecular Weight: 508.3435
• Mol File: 313673-23-3.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: (4-methoxy-3-nitrobenzyl)(triphenyl)phosphonium bromide(CAS DataBase Reference)
• NIST Chemistry Reference: (4-methoxy-3-nitrobenzyl)(triphenyl)phosphonium bromide(313673-23-3)
• EPA Substance Registry System: (4-methoxy-3-nitrobenzyl)(triphenyl)phosphonium bromide(313673-23-3)

Safety Data

• Hazardous Substances Data: 313673-23-3(Hazardous Substances Data)

Upstream product

• 119-10-8 4-methoxy-3-nitrotoluene 
• 61010-34-2 3-nitro-4-methoxybenzyl bromide 
• 603-35-0 triphenylphosphine 

Relevant articles and documents

ANTIDEPRESSANT HETEROARYL DERIVATIVES OF HETEROCYCLE-FUSED BENZODIOXANS

The invention provides compounds of the Formula: (I) that are useful for the treatment of depression (including but not limited to major depressive disorder, childhood depression and dysthymia), anxiety, panic disorder, post-traumatic stress disorder, premenstrual dysphoric disorder (also known as pre- menstrual syndrome), attention deficit disorder (with and without hyperactivity), obsessive compulsive disorder, social anxiety disorder, generalized anxiety disorder, obesity, eating disorders such as anorexia nervosa, bulimia nervosa, vasomotor flushing, cocaine and alcohol addiction, sexual dysfunction and related illnesses. The compounds are able to block the recptake of serotonin and are modulators at brain 5HT1A serotonin receptors.

Method for preparing Combretastatin

The invention concerns novel methods for preparing Combretastatin by Wittig condensation between nitromethoxy-benzaldehyde and a trimethoxybenzyl phosphonium salt or inversely a nitromethoxybenzyl phosphonium salt with trimethoxybenzylaldehyde or further by a Wittig reaction on the same derivatives whereof the nitro function has been reduced into an amino group.

Synthesis and biological evaluation of aryl azide derivatives of combretastatin a-4 as molecular probes for tubulin

Two new aryl azides, (Z)-1-(3'-azido-4'-methoxyphenyl)-2-(3'',4'',5''-trimethoxyphenyl)ethene 9 and (Z)-1-(4'-azido-3'-methoxyphenyl)-2-(3'',4'',5''-trimethoxyphenyl)ethene 5, modeled after the potent antitumor, antimitotic agent combretastatin A-4 (CA-4)