313681-72-0

Upstream product

• 108-24-7 acetic anhydride 
• 825-90-1 sodium p-hydroxybenzenesulfonate 
• 7134-04-5 6-hydroxy-toluene-3-sulfonic acid 
• 108-95-2 phenol 

Relevant academic research and scientific papers

4-MERCAPTOPHENYL ESTER OF ACETIC ACID AND PROCESS FOR PRODUCING THE SAME

A 4-mercaptophenyl ester of acetic acid useful as a material for the synthesis of color developers, etc.; and a process for producing the ester. The 4-mercaptophenyl ester of acetic acid is represented by the formula (1): [Chemical formula 1] (1) (wherein

Inhibitors of aspartyl protease

The present invention relates to a novel class of sulfonamides which are aspartyl protease inhibitors. In one embodiment, this invention relates to a novel class of HIV aspartyl protease inhibitors characterized by specific structural and physicochemical features. This invention also relates to pharmaceutical compositions comprising these compounds. The compounds and pharmaceutical compositions of this invention are particularly well suited for inhibiting HIV-1 and HIV-2 protease activity and consequently, may be advantageously used as anti-viral agents against the HIV-1 and HIV-2 viruses. This invention also relates to methods for inhibiting the activity of HIV aspartyl protease using the compounds of this invention and methods for screening compounds for anti-HIV activity.

Structure-reactivity correlations in the dissociative hydrolysis of 2′,4′-dinitrophenyl 4-hydroxy-X-benzenesulfonates

The hydrolysis reactions of several title esters in water at 60°C follow the rate law kobs = (ka + kb[OH-])/(1 + αH/Ka), where Ka is the ionization constant of the hydroxy group of the ester and kb is the second-order rate constant for the SN2(S) attack of hydroxide ion on the ionized ester. Hammett and Br?nsted correlations are consistent with a previous proposal that the mechanism related to ka is dissociative. An unusual relationship between ka values and redox equilibrium constants for substituted quinones is found to hold: this finding further supports the dissociative nature of the pathway related to ka.