3137-60-8

Usage

Uses

Used in Organic Synthesis:
4(1H)-Pyrimidinone, 5-amino-6-chloro(9CI) is used as a building block in organic synthesis for the creation of various chemical compounds. Its unique structure allows for the formation of new molecules with potential applications in different industries.
Used in Pharmaceutical Research:
In the pharmaceutical industry, 4(1H)-Pyrimidinone, 5-amino-6-chloro(9CI) serves as a key intermediate in the development of new drugs. Its versatile chemical properties enable the synthesis of a wide range of pharmaceutical products with potential therapeutic benefits.
Used in Agrochemical Production:
4(1H)-Pyrimidinone, 5-amino-6-chloro(9CI) is also utilized in the agrochemical sector for the production of various agrochemical products. Its ability to form new compounds makes it a valuable component in the development of pesticides, herbicides, and other agricultural chemicals.
Used in Biological Research:
Due to its potential biological activity, 4(1H)-Pyrimidinone, 5-amino-6-chloro(9CI) is being studied for its therapeutic applications in the treatment of various diseases. Researchers are exploring its potential as a novel therapeutic agent, which could lead to the discovery of new treatments for a range of medical conditions.

InChI:InChI=1/C4H4ClN3O/c5-3-2(6)4(9)8-1-7-3/h1H,6H2,(H,7,8,9)

Upstream product

• 3137-56-2 6-chloro-5-nitro-pyrimidin-4-ol 
• 5413-85-4 5-amino-4,6-dichloropyridimine 
• 942149-14-6 (4-amino-5,6-dihydro-4H-cyclopenta[b]thiophen-6-yl)methanol 
• 15846-19-2 4-methoxy-5-amino-6-chloropyrimidine 

Downstream Products

• 85059-18-3 2-cyano-2-diazoacetamide 
• 85059-19-4 4-carbamoyl-5-chloro-1,2,3-triazole 
• 69785-94-0 5-Amino-4-hydroxypyrimidine 

Relevant academic research and scientific papers

Synthesis and biological evaluation of 6-substituted purinylcarbanucleosides with a cyclopenta[b]thiophene pseudosugar

The first members of a new family of heterocarbobicyclic nucleoside analogues have been synthesized from the cis/trans mixture of (4-amino-5,6-dihydro-4H-cyclopenta[b]thiophen-6-yl)methanols (cis/trans-7). The separation of the cis and trans intermediates

DIHYDROQUINAZOLIN-2-ONE DERIVATIVES AS SELECTIVE CYTOTOXIC AGENTS USEFUL IN THE TREATMENT OF HIV

The present disclosure is directed to tetrahydroquinazoline derivatives of Formula I and their use for selectively killing HIV infected GAG-POL expressing cells without concomitant cytotoxicity to HIV na?ve cells, and for the treatment or prophylaxis of infection by HIV, or for the treatment, prophylaxis or delay in the onset or progression of AIDS or AIDS Related Complex (ARC).

Design, synthesis, and anticancer evaluation of acetamide and hydrazine analogues of pyrimidine

A library of acetamide and hydrazine analogues were generated on the pyrimidine ring through a multistep reaction starting from 5-nitro-pyrimidine-4,6-diol and pyrimidine-4,6-diol, respectively. The synthesized analogues were screened for in vitro cytotoxic activity against various human cancer cell lines like HCT-1 and HT-15 (colon), MCF-7(breast), PC-3 (prostrate), SF268 (CNS) using MTT method. From the bioassay results, it was observed that even though many of the synthesized derivatives exhibited a good potency against various screened cancer cell lines, compound 14a from the acetamide series was found to show potent anticancer activity on all the tested cancer cell lines with IC50 value of 0.36μM on CNS cell line and 1.6μM on HT-21 cell line, and compound 19xxi from hydrazine series of pyrimidine showed potent activity against three tested cancer cell lines with IC50 value of 0.76μM on HT-29 cell line, 2.6μM on HCT-15, and 3.2μM on MCF-7 cell line.