69785-94-0

Usage

Uses

Used in Pharmaceutical Industry:
4(1H)-Pyrimidinone, 5-amino(9CI) is used as a reactant in the synthesis of thrombin inhibitors. It plays a crucial role in the development of analogs of MD805, which are designed to contain non-polar surrogates for arginine at the P1 position. These thrombin inhibitors have potential applications in the treatment of various medical conditions, such as blood clotting disorders and cardiovascular diseases, by regulating the activity of thrombin, a key enzyme in the blood coagulation process.

InChI:InChI=1/C4H5N3O/c5-3-1-6-2-7-4(3)8/h1-2H,5H2,(H,6,7,8)

Upstream product

• 6935-11-1 2-ethylmercapto-5-amino-3H-pyrimidin-4-one 
• 3137-60-8 5-amino-4-chloro-6-hydroxypyrimidine 
• 106289-05-8 5-Formylamino-4-hydroxypyrimidine 

Downstream Products

• 57417-53-5 5-amino-3H-pyrimidine-4-thione 
• 918880-71-4 N-(4-hydroxy-5-pyrimidinyl)-4-chloro-3-cyanobenzamide 
• 273-64-3 [1,3]oxazolo[5,4-d]pyrimidine 
• 53897-99-7 1H-1,2,3-triazole-4-carboxamide 
• 106913-63-7 C₄H₄N₄O₂ 

Relevant academic research and scientific papers

N-(HETERO)ARYL-PYRROLIDINE DERIVATIVES OF PYRAZOL-4-YL-PYRROLO[2,3-d]PYRIMIDINES AND PYRROL-3-YL-PYRROLO[2,3-d]PYRIMIDINES AS JANUS KINASE INHIBITORS

The present invention relates to N-(hetero)aryl-pyrrolidine derivatives of Formula I: which are JAK inhibitors, such as selective JAK1 inhibitors, useful in the treatment of JAK-associated diseases including, for example, inflammatory and autoimmune disorders, as well as cancer.

TRANSFORMATIONS OF SUBSTITUTED 5-AMINOPYRIMIDINES UNDER CONDITIONS OF THE DIAZOTIZATION

Reaction of nitrous acid with 4-substituted and 4,6-disubstituted 5-aminopyrimidines Ia-In produces 4-substituted and 4,5-disubstituted 1,2,3-triazoles IIa-IIv, resp.Under similar conditions, 2,5-diaminopyrimidines XIIa-XIId give N(7)-oxides of 2-amino-4-aralkylthiopyrimido-1,2,3-triazines XIIIa-XIIId, and 5-amino-4-chloropyrimidines In and X give 2-diazocyanoacetamides XIa and XIb, resp.Also described are syntheses of 5-formylaminopyrimidines XVa-XVg from glycine ethyl ester via sodium salt XVI.