313951-92-7Relevant articles and documents
First X-ray cocrystal structure of a bacterial FabH condensing enzyme and a small molecule inhibitor achieved using rational design and homology modeling
Daines, Robert A.,Pendrak, Israil,Sham, Kelvin,Van Aller, Glenn S.,Konstantinidis, Alex K.,Lonsdale, John T.,Janson, Cheryl A.,Qiu, Xiayang,Brandt, Martin,Khandekar, Sanjay S.,Silverman, Carol,Head, Martha S.
, p. 5 - 8 (2007/10/03)
The first cocrystal structure of a bacterial FabH condensing enzyme and a small molecule inhibitor is reported. The inhibitor was obtained by rational modification of a high throughput screening lead with the aid of a S. pneumoniae FabH homology model. This homology model was used to design analogues that would have both high affinity for the enzyme and appropriate aqueous solubility to facilitate cocrystallization studies.
Indole compounds useful for treating bacterial infections
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, (2008/06/13)
This invention relates to the use of compounds as inhibitors of the fatty acid synthase FabH useful in treating bacterial infections.
